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SLC16A10 solute carrier family 16 member 10 [ Homo sapiens (human) ]

Gene ID: 117247, updated on 5-Jul-2025
Official Symbol
SLC16A10provided by HGNC
Official Full Name
solute carrier family 16 member 10provided by HGNC
Primary source
HGNC:HGNC:17027
See related
Ensembl:ENSG00000112394 MIM:607550; AllianceGenome:HGNC:17027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAT1; MCT10; PRO0813
Summary
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
Expression
Broad expression in placenta (RPKM 4.2), skin (RPKM 2.5) and 19 other tissues See more
Orthologs
NEW
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See SLC16A10 in Genome Data Viewer
Location:
6q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (111087503..111231194)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (112266105..112414313)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111408706..111552397)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901375 Neighboring gene ribosome production factor 2 homolog Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:111337799-111338443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17472 Neighboring gene glutathione S-transferase mu 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17473 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111409089-111409589 Neighboring gene RNA, U6 small nuclear 960, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:111428108-111429307 Neighboring gene small nucleolar RNA, C/D box 166 Neighboring gene uncharacterized LOC124901377 Neighboring gene SLC60A2 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr6:111573581-111573781 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111575060-111575706 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111575707-111576354 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111576355-111577001 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111577002-111577648 Neighboring gene uncharacterized LOC124901378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24942 Neighboring gene Sharpr-MPRA regulatory region 12211 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_87657 Neighboring gene solute carrier family 60 member 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of solute carrier family 16 (aromatic amino acid transporter), member 10 (SLC16A10) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-phenylalanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-phenylalanine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables L-tryptophan transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-tryptophan transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables L-tyrosine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-tyrosine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables aromatic amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aromatic amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxylic acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thyroid hormone transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thyroid hormone transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid transport TAS
Traceable Author Statement
more info
 
involved_in aromatic amino acid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aromatic amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in aromatic amino acid transport TAS
Traceable Author Statement
more info
PubMed 
involved_in carboxylic acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phenylalanine transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within_negative_effect thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
 
involved_in thyroid hormone transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thyroid hormone transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in tryptophan transport IEA
Inferred from Electronic Annotation
more info
 
involved_in tyrosine transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
monocarboxylate transporter 10
Names
MCT 10
T-type amino acid transporter 1
aromatic amino acid transporter 1
solute carrier family 16 (aromatic amino acid transporter), member 10
solute carrier family 16 (monocarboxylic acid transporters), member 10
solute carrier family 16, member 10 (aromatic amino acid transporter)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018593.5NP_061063.2  monocarboxylate transporter 10

    See identical proteins and their annotated locations for NP_061063.2

    Status: VALIDATED

    Source sequence(s)
    AB057445, AL360227, BC017968
    Consensus CDS
    CCDS5089.1
    UniProtKB/Swiss-Prot
    B3KWY0, Q6ZMG0, Q8TF71, Q8WVI5
    Related
    ENSP00000357844.4, ENST00000368851.10
    Conserved Domains (2) summary
    cd06174
    Location:71470
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:67487
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    111087503..111231194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418167.1XP_047274123.1  monocarboxylate transporter 10 isoform X2

    UniProtKB/TrEMBL
    Q05BR4
  2. XM_011535422.3XP_011533724.1  monocarboxylate transporter 10 isoform X2

    See identical proteins and their annotated locations for XP_011533724.1

    UniProtKB/TrEMBL
    Q05BR4
    Conserved Domains (1) summary
    cd06174
    Location:71254
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_006715329.3XP_006715392.1  monocarboxylate transporter 10 isoform X1

    See identical proteins and their annotated locations for XP_006715392.1

    UniProtKB/TrEMBL
    Q05BR4
    Conserved Domains (1) summary
    cl28910
    Location:70316
    MFS; Major Facilitator Superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    112266105..112414313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354195.1XP_054210170.1  monocarboxylate transporter 10 isoform X2

    UniProtKB/TrEMBL
    Q05BR4
  2. XM_054354196.1XP_054210171.1  monocarboxylate transporter 10 isoform X2

    UniProtKB/TrEMBL
    Q05BR4
  3. XM_054354194.1XP_054210169.1  monocarboxylate transporter 10 isoform X1

    UniProtKB/TrEMBL
    Q05BR4