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SLC16A10 solute carrier family 16 member 10 [ Homo sapiens (human) ]

Gene ID: 117247, updated on 7-Jun-2020

Summary

Official Symbol
SLC16A10provided by HGNC
Official Full Name
solute carrier family 16 member 10provided by HGNC
Primary source
HGNC:HGNC:17027
See related
Ensembl:ENSG00000112394 MIM:607550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAT1; MCT10; PRO0813
Summary
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
Expression
Broad expression in placenta (RPKM 4.2), skin (RPKM 2.5) and 19 other tissues See more
Orthologs

Genomic context

See SLC16A10 in Genome Data Viewer
Location:
6q21
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (111087503..111231194)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111408728..111544608)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 906, pseudogene Neighboring gene ribosome production factor 2 homolog Neighboring gene glutathione S-transferase mu 2 pseudogene 1 Neighboring gene RNA, U6 small nuclear 960, pseudogene Neighboring gene small nucleolar RNA, C/D box 166 Neighboring gene uncharacterized LOC107986521 Neighboring gene major facilitator superfamily domain containing 4B Neighboring gene REV3 like, DNA directed polymerase zeta catalytic subunit Neighboring gene FCF1 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of solute carrier family 16 (aromatic amino acid transporter), member 10 (SLC16A10) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
aromatic amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
amino acid transport TAS
Traceable Author Statement
more info
 
aromatic amino acid transport TAS
Traceable Author Statement
more info
PubMed 
monocarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
 
thyroid-stimulating hormone secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane TAS
Traceable Author Statement
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
monocarboxylate transporter 10
Names
MCT 10
T-type amino acid transporter 1
aromatic amino acid transporter 1
solute carrier family 16 (aromatic amino acid transporter), member 10
solute carrier family 16 (monocarboxylic acid transporters), member 10
solute carrier family 16, member 10 (aromatic amino acid transporter)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018593.5NP_061063.2  monocarboxylate transporter 10

    See identical proteins and their annotated locations for NP_061063.2

    Status: VALIDATED

    Source sequence(s)
    AB057445, AL360227, BC017968
    Consensus CDS
    CCDS5089.1
    UniProtKB/Swiss-Prot
    Q8TF71
    Related
    ENSP00000357844.4, ENST00000368851.10
    Conserved Domains (2) summary
    cd06174
    Location:71470
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:67487
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    111087503..111231194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535422.2XP_011533724.1  monocarboxylate transporter 10 isoform X2

    See identical proteins and their annotated locations for XP_011533724.1

    Conserved Domains (1) summary
    cd06174
    Location:71254
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  2. XM_006715329.2XP_006715392.1  monocarboxylate transporter 10 isoform X1

    See identical proteins and their annotated locations for XP_006715392.1

    Conserved Domains (1) summary
    cd06174
    Location:71254
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_017010237.1XP_016865726.1  monocarboxylate transporter 10 isoform X3

RNA

  1. XR_001743158.1 RNA Sequence

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