SLC16A10 solute carrier family 16 member 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC16A10provided by HGNC
Official Full Name: solute carrier family 16 member 10provided by HGNC
Primary source: HGNC:HGNC:17027
See related: Ensembl:ENSG00000112394 MIM:607550; AllianceGenome:HGNC:17027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TAT1; MCT10; PRO0813
Summary: SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
Expression: Broad expression in placenta (RPKM 4.2), skin (RPKM 2.5) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (111087503..111231194)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (112266105..112414313)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (111408706..111552397)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits.
Title: Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits.
Molecular predictor of TaT1 patients.
Title: ΔNp63 transcript loss in bladder cancer constitutes an independent molecular predictor of TaT1 patients post-treatment relapse and progression.
In the MCT10 modeled structure, N81 appeared to protrude into the putative trajectory of tryptophan.
Title: Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae.
the aim of this study was to examine if MCT8 and MCT10 increase the availability of triiodothyronine for its nuclear receptor.
Title: Effects of thyroid hormone transporters MCT8 and MCT10 on nuclear activity of T3.
High TAT1 expression is associated with metastasis and recurrence in endometrial cancer.
Title: Monitoring the treatment outcome in endometrial cancer patients by CEA and TATI.
Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.
Title: The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.
monocarboxylate transporter 10 facilitates bromoacetyl [(125)I] iodothyronine transport, but is not labeled by it
Title: The thyroid hormone transporters MCT8 and MCT10 transport the affinity-label N-bromoacetyl-[(125)I]T3 but are not modified by it.
The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis.
Title: Expression of thyroid hormone transporters in the human hypothalamus.
Increased MCT8 and decreased MCT10 expression within placentae of pregnancies complicated by IUGR may contribute to aberrant development of the fetoplacental unit.
Title: Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction.
MCT10 is at least as active a thyroid hormone transporter as hMCT8, and that both transporters facilitate iodothyronine uptake as well as efflux.
Title: Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Human metabolic individuality in biomedical and pharmaceutical research. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of solute carrier family 16 (aromatic amino acid transporter), member 10 (SLC16A10) in peptide-treated PBMCs	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N30257 (e-PCR)
- UniSTS:53605

RH124087 (e-PCR)
- UniSTS:134568

SLC16A10_831 (e-PCR)
- UniSTS:277719

EV4Pm (e-PCR)
- UniSTS:30450

Homology

Homologs of the SLC16A10 gene: The SLC16A10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 468 organisms have orthologs with human gene SLC16A10
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-phenylalanine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tryptophan transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tyrosine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amino acid transmembrane transporter activity	TAS Traceable Author Statement more info
enables aromatic amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monocarboxylic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thyroid hormone transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid transport	TAS Traceable Author Statement more info
involved_in aromatic amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in aromatic amino acid transport	TAS Traceable Author Statement more info	PubMed
involved_in phenylalanine transport	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone transport	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid-stimulating hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in tryptophan transport	IEA Inferred from Electronic Annotation more info
involved_in tyrosine transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: monocarboxylate transporter 10

Names: MCT 10; T-type amino acid transporter 1; aromatic amino acid transporter 1; solute carrier family 16 (aromatic amino acid transporter), member 10; solute carrier family 16 (monocarboxylic acid transporters), member 10; solute carrier family 16, member 10 (aromatic amino acid transporter)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018593.5 → NP_061063.2 monocarboxylate transporter 10

See identical proteins and their annotated locations for NP_061063.2

Status: VALIDATED

Source sequence(s)

AB057445, AL360227, BC017968

Consensus CDS

CCDS5089.1

UniProtKB/Swiss-Prot

Q8TF71, Q8WVI5

Related

ENSP00000357844.4, ENST00000368851.10

Conserved Domains (2) summary

cd06174
Location:71 → 470

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00892
Location:67 → 487

2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

111087503..111231194

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418167.1 → XP_047274123.1 monocarboxylate transporter 10 isoform X2
XM_011535422.3 → XP_011533724.1 monocarboxylate transporter 10 isoform X2

See identical proteins and their annotated locations for XP_011533724.1

Conserved Domains (1) summary

cd06174
Location:71 → 254

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
XM_006715329.3 → XP_006715392.1 monocarboxylate transporter 10 isoform X1

See identical proteins and their annotated locations for XP_006715392.1

Conserved Domains (1) summary

cl28910
Location:70 → 316

MFS; Major Facilitator Superfamily