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FTSJ3 FtsJ RNA 2'-O-methyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 117246, updated on 3-May-2020

Summary

Official Symbol
FTSJ3provided by HGNC
Official Full Name
FtsJ RNA 2'-O-methyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:17136
See related
Ensembl:ENSG00000108592 MIM:618411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPB1; EPCS3
Summary
Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 14.7), lymph node (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See FTSJ3 in Genome Data Viewer
Location:
17q23.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (63819433..63827663, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61896793..61905031, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 47 Neighboring gene DEAD-box helicase 42 Neighboring gene uncharacterized LOC107984986 Neighboring gene proteasome 26S subunit, ATPase 5 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20062

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA (guanine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA (uridine-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
enzyme-directed rRNA 2'-O-methylation IEA
Inferred from Electronic Annotation
more info
 
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Names
2'-O-ribose RNA methyltransferase SPB1 homolog
FtsJ RNA methyltransferase homolog 3
FtsJ homolog 3
SPB1 RNA methyltransferase homolog
pre-rRNA processing protein FTSJ3
protein ftsJ homolog 3
putative rRNA methyltransferase 3
rRNA (uridine-2'-O-)-methyltransferase 3
NP_060117.3
XP_024306330.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017647.4NP_060117.3  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

    See identical proteins and their annotated locations for NP_060117.3

    Status: REVIEWED

    Source sequence(s)
    AF147378, AK095861, AK315010, BM914774
    Consensus CDS
    CCDS11644.1
    UniProtKB/Swiss-Prot
    Q8IY81
    Related
    ENSP00000396673.2, ENST00000427159.7
    Conserved Domains (3) summary
    COG0293
    Location:8203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    pfam07780
    Location:644834
    Spb1_C; Spb1 C-terminal domain
    pfam11861
    Location:232400
    DUF3381; Domain of unknown function (DUF3381)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    63819433..63827663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450562.1XP_024306330.1  pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 isoform X1

    Conserved Domains (2) summary
    COG0293
    Location:8203
    RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    pfam11861
    Location:232400
    DUF3381; Domain of unknown function (DUF3381)
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