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PLAAT5 phospholipase A and acyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 117245, updated on 22-Aug-2021

Summary

Official Symbol
PLAAT5provided by HGNC
Official Full Name
phospholipase A and acyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:24978
See related
Ensembl:ENSG00000168004 MIM:611474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RLP1; iNAT; HRLP5; HRSL5; HRASLS5; PLAAT-5
Expression
Biased expression in testis (RPKM 31.0), fat (RPKM 23.9) and 1 other tissue See more
Orthologs
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Genomic context

See PLAAT5 in Genome Data Viewer
Location:
11q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63461404..63491203, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63228876..63258639, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 10 Neighboring gene solute carrier family 22 member 9 Neighboring gene zinc finger protein 91 pseudogene Neighboring gene galectin 12 Neighboring gene TMSB4X pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase A and acyltransferase 5
Names
Ca(2+)-independent N-acyltransferase
H-rev107-like protein 5
HRAS like suppressor family member 5
HRAS-like suppressor 5
calcium-independent phosphatidylethanolamine N-acyltransferase
lecithin-retinol acyltransferase (LRAT)-like protein-1
phospholipase A/acyltransferase-5
testicular tissue protein Li 90
NP_001140200.2
NP_001140201.2
NP_473449.2
XP_011543053.1
XP_011543054.1
XP_011543055.1
XP_016872661.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146728.2NP_001140200.2  phospholipase A and acyltransferase 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1 that results in a frameshift. It encodes isoform 3, which has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000484, AP001591
    Consensus CDS
    CCDS53647.1
    Related
    ENSP00000443873.1, ENST00000539221.5
    Conserved Domains (1) summary
    pfam04970
    Location:142233
    LRAT; Lecithin retinol acyltransferase
  2. NM_001146729.2NP_001140201.2  phospholipase A and acyltransferase 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AP000484, AP001591
    Consensus CDS
    CCDS53646.1
    Related
    ENSP00000444809.1, ENST00000540857.6
    Conserved Domains (1) summary
    pfam04970
    Location:132235
    LRAT; Lecithin retinol acyltransferase
  3. NM_054108.4NP_473449.2  phospholipase A and acyltransferase 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP000484, AP001591
    Consensus CDS
    CCDS8044.1
    Related
    ENSP00000301790.4, ENST00000301790.4
    Conserved Domains (1) summary
    pfam04970
    Location:142245
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63461404..63491203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544752.2XP_011543054.1  phospholipase A and acyltransferase 5 isoform X2

    Conserved Domains (1) summary
    pfam04970
    Location:57133
    LRAT; Lecithin retinol acyltransferase
  2. XM_011544751.3XP_011543053.1  phospholipase A and acyltransferase 5 isoform X1

    Conserved Domains (1) summary
    pfam04970
    Location:131234
    LRAT; Lecithin retinol acyltransferase
  3. XM_017017172.1XP_016872661.1  phospholipase A and acyltransferase 5 isoform X3

    Conserved Domains (1) summary
    pfam04970
    Location:22125
    LRAT; Lecithin retinol acyltransferase
  4. XM_011544753.1XP_011543055.1  phospholipase A and acyltransferase 5 isoform X3

    Conserved Domains (1) summary
    pfam04970
    Location:22125
    LRAT; Lecithin retinol acyltransferase

RNA

  1. XR_001747767.1 RNA Sequence

    Related
    ENST00000536887.5
  2. XR_428910.1 RNA Sequence

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