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Stk33 serine/threonine kinase 33 [ Mus musculus (house mouse) ]

Gene ID: 117229, updated on 8-Nov-2022

Summary

Official Symbol
Stk33provided by MGI
Official Full Name
serine/threonine kinase 33provided by MGI
Primary source
MGI:MGI:2152419
See related
Ensembl:ENSMUSG00000031027 AllianceGenome:MGI:2152419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921505G21Rik
Summary
Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; heart; lung; sensory organ; and testis. Orthologous to human STK33 (serine/threonine kinase 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 30.5) and CNS E11.5 (RPKM 1.6) See more
Orthologs
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Genomic context

See Stk33 in Genome Data Viewer
Location:
7 E3; 7 57.21 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108878270..109038375, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109279213..109439168, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32563 Neighboring gene predicted gene, 51463 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 pseudogene Neighboring gene RIKEN cDNA 1700095J03 gene Neighboring gene tripartite motif-containing 66 Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mitotic DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 33
NP_001342074.1
NP_473444.1
XP_006507287.1
XP_006507288.1
XP_006507289.1
XP_006507291.1
XP_006507292.1
XP_011239951.1
XP_011239952.1
XP_011239954.1
XP_017177431.1
XP_017177432.1
XP_030097864.1
XP_030097865.1
XP_036008474.1
XP_036008475.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355145.1NP_001342074.1  serine/threonine-protein kinase 33 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124457, AC147221, AC165143
    Consensus CDS
    CCDS90306.1
    UniProtKB/TrEMBL
    D3YWA6
    Conserved Domains (1) summary
    cl21453
    Location:1254
    PKc_like; Protein Kinases, catalytic domain
  2. NM_054103.1NP_473444.1  serine/threonine-protein kinase 33 isoform 1

    See identical proteins and their annotated locations for NP_473444.1

    Status: VALIDATED

    Source sequence(s)
    AK014819, AW061264, BB614724
    Consensus CDS
    CCDS52358.1
    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Related
    ENSMUSP00000102356.3, ENSMUST00000106745.9
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    108878270..109038375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507224.2XP_006507287.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_006507287.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Related
    ENSMUSP00000112515.2, ENSMUST00000121748.8
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006507226.4XP_006507289.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_006507289.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Related
    ENSMUSP00000087897.5, ENSMUST00000090414.11
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  3. XM_030242005.2XP_030097865.1  serine/threonine-protein kinase 33 isoform X5

    UniProtKB/TrEMBL
    D3YWA6
    Related
    ENSMUSP00000112560.2, ENSMUST00000121378.2
    Conserved Domains (1) summary
    cl21453
    Location:1254
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036152582.1XP_036008475.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q4A1D4
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  5. XM_030242004.1XP_030097864.1  serine/threonine-protein kinase 33 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:72340
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011241652.2XP_011239954.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011239954.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  7. XM_006507228.4XP_006507291.1  serine/threonine-protein kinase 33 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:72340
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017321942.2XP_017177431.1  serine/threonine-protein kinase 33 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:72340
    PKc_like; Protein Kinases, catalytic domain
  9. XM_006507225.4XP_006507288.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_006507288.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011241650.3XP_011239952.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011239952.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  11. XM_011241649.3XP_011239951.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011239951.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  12. XM_036152581.1XP_036008474.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q4A1D4
    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain
  13. XM_017321943.2XP_017177432.1  serine/threonine-protein kinase 33 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:72340
    PKc_like; Protein Kinases, catalytic domain
  14. XM_006507229.4XP_006507292.1  serine/threonine-protein kinase 33 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:109377
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003946376.2 RNA Sequence