U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MRGPRX3 MAS related GPR family member X3 [ Homo sapiens (human) ]

Gene ID: 117195, updated on 17-Sep-2024

Summary

Official Symbol
MRGPRX3provided by HGNC
Official Full Name
MAS related GPR family member X3provided by HGNC
Primary source
HGNC:HGNC:17980
See related
Ensembl:ENSG00000179826 MIM:607229; AllianceGenome:HGNC:17980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR; MRGX3; SNSR1; SNSR2
Summary
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MRGPRX3 in Genome Data Viewer
Location:
11p15.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18120955..18138488)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18216477..18233987)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18142502..18160035)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 5 Neighboring gene serum amyloid A3, pseudogene Neighboring gene MAS related GPR family member X12, pseudogene Neighboring gene MAS related GPR family member X4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mas-related G-protein coupled receptor member X3
Names
G protein-coupled receptor MRGX3
G protein-coupled receptor SNSR1
G protein-coupled receptor SNSR2
MAS-related GPR, member X3
mas-related GPCR member X3
sensory neuron-specific G-protein coupled receptor 1/2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370464.1NP_001357393.1  mas-related G-protein coupled receptor member X3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC090099
    Consensus CDS
    CCDS7830.1
    UniProtKB/Swiss-Prot
    B0M0L1, Q8TDE0, Q8TDE1, Q96LB0
    UniProtKB/TrEMBL
    W8W3E1
    Related
    ENSP00000481943.1, ENST00000621697.2
    Conserved Domains (1) summary
    cd15106
    Location:28299
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_054031.4NP_473372.3  mas-related G-protein coupled receptor member X3

    See identical proteins and their annotated locations for NP_473372.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC090099, BC067292
    Consensus CDS
    CCDS7830.1
    UniProtKB/Swiss-Prot
    B0M0L1, Q8TDE0, Q8TDE1, Q96LB0
    UniProtKB/TrEMBL
    W8W3E1
    Related
    ENSP00000379571.2, ENST00000396275.2
    Conserved Domains (1) summary
    cd15106
    Location:28299
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18120955..18138488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18216477..18233987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)