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MRGPRX2 MAS related GPR family member X2 [ Homo sapiens (human) ]

Gene ID: 117194, updated on 2-Oct-2022

Summary

Official Symbol
MRGPRX2provided by HGNC
Official Full Name
MAS related GPR family member X2provided by HGNC
Primary source
HGNC:HGNC:17983
See related
Ensembl:ENSG00000183695 MIM:607228; AllianceGenome:HGNC:17983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGRG3; MRGX2
Summary
Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MRGPRX2 in Genome Data Viewer
Location:
11p15.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (19054455..19060717, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19174588..19180847, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19076002..19082264, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member X10, pseudogene Neighboring gene MAS related GPR family member X9, pseudogene Neighboring gene zinc finger DHHC-type palmitoyltransferase 13 Neighboring gene VISTA enhancer hs2144 Neighboring gene CSRP3 and E2F8 antisense RNA 1 Neighboring gene cysteine and glycine rich protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mast cell secretagogue receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables neuropeptide binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of pain NAS
Non-traceable Author Statement
more info
PubMed 
involved_in sleep NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mas-related G-protein coupled receptor member X2
Names
G protein-coupled receptor MRGX2
MAS-related GPR, member X2
Mas-related G protein-coupled receptor G3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303615.2NP_001290544.1  mas-related G-protein coupled receptor member X2

    See identical proteins and their annotated locations for NP_001290544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027026, BC063450, HY005030
    Consensus CDS
    CCDS7847.1
    UniProtKB/Swiss-Prot
    Q96LB1, W8W3L5
    Conserved Domains (1) summary
    cd15106
    Location:31308
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_054030.4NP_473371.1  mas-related G-protein coupled receptor member X2

    See identical proteins and their annotated locations for NP_473371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027026, BC063450
    Consensus CDS
    CCDS7847.1
    UniProtKB/Swiss-Prot
    Q96LB1, W8W3L5
    Related
    ENSP00000333800.2, ENST00000329773.3
    Conserved Domains (1) summary
    cd15106
    Location:31308
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    19054455..19060717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    19174588..19180847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)