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Ampd3 adenosine monophosphate deaminase 3 [ Mus musculus (house mouse) ]

Gene ID: 11717, updated on 27-Nov-2024

Summary

Official Symbol
Ampd3provided by MGI
Official Full Name
adenosine monophosphate deaminase 3provided by MGI
Primary source
MGI:MGI:1096344
See related
Ensembl:ENSMUSG00000005686 AllianceGenome:MGI:1096344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in ovary adult (RPKM 15.7), subcutaneous fat pad adult (RPKM 12.5) and 25 other tissues See more
Orthologs
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Genomic context

See Ampd3 in Genome Data Viewer
Location:
7 E3; 7 57.85 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110367291..110411612)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110767790..110812409)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19832 Neighboring gene predicted gene, 39068 Neighboring gene RIKEN cDNA B430319F04 gene Neighboring gene predicted gene, 39069 Neighboring gene ring finger protein 141 Neighboring gene STARR-positive B cell enhancer ABC_E2250 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene STARR-seq mESC enhancer starr_19833 Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene predicted gene 16336

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables AMP deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables AMP deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables AMP deaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ADP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ADP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ADP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in AMP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within AMP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in AMP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ATP metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ATP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GTP metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in GTP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within IMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in IMP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in IMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
AMP deaminase 3
Names
AMP deaminase H-type
heart-type AMPD
NP_001263230.1
NP_001359368.1
NP_001359370.1
NP_001398841.1
NP_001398842.1
NP_001398843.1
NP_001398844.1
NP_033797.2
XP_030097862.1
XP_036008472.1
XP_036008473.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276301.2NP_001263230.1  AMP deaminase 3 isoform 1

    See identical proteins and their annotated locations for NP_001263230.1

    Status: REVIEWED

    Source sequence(s)
    AC122844
    Consensus CDS
    CCDS21747.1
    UniProtKB/Swiss-Prot
    O08739, O88692, Q8CFR4
    Related
    ENSMUSP00000130495.2, ENSMUST00000170374.8
    Conserved Domains (1) summary
    TIGR01429
    Location:146752
    AMP_deaminase; AMP deaminase
  2. NM_001372439.2NP_001359368.1  AMP deaminase 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC122844
    Conserved Domains (1) summary
    TIGR01429
    Location:154760
    AMP_deaminase; AMP deaminase
  3. NM_001372441.2NP_001359370.1  AMP deaminase 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC122844
    Consensus CDS
    CCDS90309.1
    UniProtKB/TrEMBL
    A0A1L1SRX2
    Related
    ENSMUSP00000149655.2, ENSMUST00000213373.2
    Conserved Domains (1) summary
    TIGR01429
    Location:155761
    AMP_deaminase; AMP deaminase
  4. NM_001411912.1NP_001398841.1  AMP deaminase 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC122844
    UniProtKB/Swiss-Prot
    O08739, O88692, Q8CFR4
  5. NM_001411913.1NP_001398842.1  AMP deaminase 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC122844
    UniProtKB/Swiss-Prot
    O08739, O88692, Q8CFR4
  6. NM_001411914.1NP_001398843.1  AMP deaminase 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC122844
    UniProtKB/Swiss-Prot
    O08739, O88692, Q8CFR4
  7. NM_001411915.1NP_001398844.1  AMP deaminase 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC122844
  8. NM_009667.4NP_033797.2  AMP deaminase 3 isoform 1

    See identical proteins and their annotated locations for NP_033797.2

    Status: REVIEWED

    Source sequence(s)
    AC122844
    Consensus CDS
    CCDS21747.1
    UniProtKB/Swiss-Prot
    O08739, O88692, Q8CFR4
    Related
    ENSMUSP00000005829.7, ENSMUST00000005829.13
    Conserved Domains (1) summary
    TIGR01429
    Location:146752
    AMP_deaminase; AMP deaminase

RNA

  1. NR_183246.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC122844

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    110367291..110411612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242002.2XP_030097862.1  AMP deaminase 3 isoform X2

    UniProtKB/Swiss-Prot
    O08739, O88692, Q8CFR4
    Conserved Domains (1) summary
    TIGR01429
    Location:146752
    AMP_deaminase; AMP deaminase
  2. XM_036152580.1XP_036008473.1  AMP deaminase 3 isoform X3

    Conserved Domains (1) summary
    cl00281
    Location:154485
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  3. XM_036152579.1XP_036008472.1  AMP deaminase 3 isoform X2

    UniProtKB/Swiss-Prot
    O08739, O88692, Q8CFR4
    Conserved Domains (1) summary
    TIGR01429
    Location:146752
    AMP_deaminase; AMP deaminase

RNA

  1. XR_378209.5 RNA Sequence