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Bdh1 3-hydroxybutyrate dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117099, updated on 10-Jul-2024

Summary

Official Symbol
Bdh1provided by RGD
Official Full Name
3-hydroxybutyrate dehydrogenase 1provided by RGD
Primary source
RGD:620131
See related
EnsemblRapid:ENSRNOG00000001736 AllianceGenome:RGD:620131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bdh
Summary
Enables 3-hydroxybutyrate dehydrogenase activity and phospholipid binding activity. Involved in several processes, including animal organ development; response to corticosterone; and response to peptide hormone. Located in mitochondrial inner membrane. Biomarker of hyperthyroidism. Orthologous to human BDH1 (3-hydroxybutyrate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 732.0), Heart (RPKM 140.3) and 5 other tissues See more
Orthologs
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Genomic context

See Bdh1 in Genome Data Viewer
Location:
11q22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82806125..82848133, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (69302534..69343173, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72577547..72619435, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550974 Neighboring gene uncharacterized LOC120095674 Neighboring gene uncharacterized LOC134481095 Neighboring gene uncharacterized LOC134481093 Neighboring gene uncharacterized LOC134481094 Neighboring gene apolipoprotein D

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC94818

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-hydroxybutyrate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3-hydroxybutyrate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3-hydroxybutyrate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3-hydroxybutyrate dehydrogenase activity TAS
Traceable Author Statement
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adipose tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in liver development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to growth hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in matrix side of mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Names
3-hydroxybutyrate dehydrogenase (heart, mitochondrial)
3-hydroxybutyrate dehydrogenase, type 1
NP_446447.2
XP_006248540.1
XP_038943838.1
XP_038943839.1
XP_063126315.1
XP_063126316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053995.3NP_446447.2  D-beta-hydroxybutyrate dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_446447.2

    Status: PROVISIONAL

    Source sequence(s)
    BC085916
    UniProtKB/Swiss-Prot
    P29147, Q5U2Q2
    UniProtKB/TrEMBL
    A0A0G2JSH2, A6IRW3
    Related
    ENSRNOP00000002366.3, ENSRNOT00000002366.7
    Conserved Domains (1) summary
    cd09805
    Location:57342
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    82806125..82848133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248478.5XP_006248540.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006248540.1

    UniProtKB/Swiss-Prot
    P29147, Q5U2Q2
    UniProtKB/TrEMBL
    A0A0G2JSH2, A6IRW3
    Conserved Domains (1) summary
    cd09805
    Location:57342
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
  2. XM_063270245.1XP_063126315.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P29147, Q5U2Q2
    UniProtKB/TrEMBL
    A0A0G2JSH2, A6IRW3
  3. XM_063270246.1XP_063126316.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P29147, Q5U2Q2
    UniProtKB/TrEMBL
    A0A0G2JSH2, A6IRW3
  4. XM_039087910.2XP_038943838.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P29147, Q5U2Q2
    UniProtKB/TrEMBL
    A0A0G2JSH2, A6IRW3
    Conserved Domains (1) summary
    cd09805
    Location:57342
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
  5. XM_039087911.2XP_038943839.1  D-beta-hydroxybutyrate dehydrogenase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P29147, Q5U2Q2
    UniProtKB/TrEMBL
    A0A0G2JSH2, A6IRW3
    Conserved Domains (1) summary
    cd09805
    Location:57342
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs