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Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117098, updated on 5-Mar-2024

Summary

Official Symbol
Pdha2provided by RGD
Official Full Name
pyruvate dehydrogenase E1 subunit alpha 2provided by RGD
Primary source
RGD:620095
See related
AllianceGenome:RGD:620095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pdhal
Summary
Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Orthologous to human PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Pdha2 in Genome Data Viewer
Location:
2q44
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (232545550..232547098, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (229872300..229873848, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (246736449..246737997, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100956 Neighboring gene uncharacterized LOC134485985 Neighboring gene uncharacterized LOC103691720 Neighboring gene uncharacterized LOC134485986 Neighboring gene unc-5 netrin receptor C Neighboring gene uncharacterized LOC134485692

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in acetyl-CoA biosynthetic process from pyruvate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pyruvate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Names
PDHE1-A type II
pyruvate dehydrogenase (lipoamide) alpha 2
pyruvate dehydrogenase E1 alpha 2 subunit
pyruvate dehydrogenase alpha 2
NP_446446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053994.2NP_446446.1  pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_446446.1

    Status: VALIDATED

    Source sequence(s)
    BC078757
    UniProtKB/Swiss-Prot
    Q06437
    UniProtKB/TrEMBL
    A6HW52
    Conserved Domains (1) summary
    TIGR03182
    Location:59371
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    232545550..232547098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)