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Myo1b myosin Ib [ Rattus norvegicus (Norway rat) ]

Gene ID: 117057, updated on 6-Sep-2021

Summary

Official Symbol
Myo1bprovided by RGD
Official Full Name
myosin Ibprovided by RGD
Primary source
RGD:70994
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Myr1
Summary
alternative splice forms Myr1a-c bind F-actin; splice form Myr1a may play a role in neuronal development [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 408.9), Liver (RPKM 370.1) and 9 other tissues See more
Orthologs
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Genomic context

See Myo1b in Genome Data Viewer
Location:
9q22
Exon count:
34
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (49690043..49852373)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (54706005..54766054)

Chromosome 9 - NC_051344.1Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene uncharacterized LOC103690550 Neighboring gene thymosin beta-10 pseudogene Neighboring gene 60S ribosomal protein L12-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microfilament motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament-based movement IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in post-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transferrin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Ib
Names
MMI-alpha
MMIa
myosin I alpha
myosin heavy chain myr 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053986.2NP_446438.1  unconventional myosin-Ib

    See identical proteins and their annotated locations for NP_446438.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000214
    UniProtKB/Swiss-Prot
    Q05096
    Conserved Domains (3) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9411118
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051344.1 Reference mRatBN7.2 Primary Assembly

    Range
    49690043..49852373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082948.1XP_038938876.1  unconventional myosin-Ib isoform X1

    Conserved Domains (3) summary
    smart00015
    Location:762784
    IQ; Calmodulin-binding motif
    cd01378
    Location:29701
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9541131
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. XM_039082952.1XP_038938880.1  unconventional myosin-Ib isoform X4

    Conserved Domains (3) summary
    smart00015
    Location:762784
    IQ; Calmodulin-binding motif
    cd01378
    Location:29701
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9251102
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. XM_039082954.1XP_038938882.1  unconventional myosin-Ib isoform X6

    Conserved Domains (3) summary
    smart00015
    Location:762784
    IQ; Calmodulin-binding motif
    cd01378
    Location:29701
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8961073
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  4. XM_039082950.1XP_038938878.1  unconventional myosin-Ib isoform X2

    Conserved Domains (3) summary
    smart00015
    Location:760782
    IQ; Calmodulin-binding motif
    cd01378
    Location:29699
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9521129
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  5. XM_039082951.1XP_038938879.1  unconventional myosin-Ib isoform X3

    Conserved Domains (3) summary
    smart00015
    Location:751773
    IQ; Calmodulin-binding motif
    cd01378
    Location:29690
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9431120
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  6. XM_039082953.1XP_038938881.1  unconventional myosin-Ib isoform X5

    Conserved Domains (3) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9121089
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  7. XM_039082955.1XP_038938883.1  unconventional myosin-Ib isoform X7

    Conserved Domains (3) summary
    smart00015
    Location:749771
    IQ; Calmodulin-binding motif
    cd01378
    Location:29688
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8831060
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  8. XM_039082949.1XP_038938877.1  unconventional myosin-Ib isoform X1

    Conserved Domains (3) summary
    smart00015
    Location:762784
    IQ; Calmodulin-binding motif
    cd01378
    Location:29701
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:9541131
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  9. XM_039082956.1XP_038938884.1  unconventional myosin-Ib isoform X8

    Conserved Domains (3) summary
    smart00015
    Location:616638
    IQ; Calmodulin-binding motif
    pfam06017
    Location:808985
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    cl22853
    Location:79555
    Motor_domain; Myosin and Kinesin motor domain
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