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Eif4e eukaryotic translation initiation factor 4E [ Rattus norvegicus (Norway rat) ]

Gene ID: 117045, updated on 12-Aug-2018

Summary

Official Symbol
Eif4eprovided by RGD
Official Full Name
eukaryotic translation initiation factor 4Eprovided by RGD
Primary source
RGD:69647
See related
Ensembl:ENSRNOG00000052343 Vega:OTTRNOG00000002187
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
binds to the mRNA 7-methylguanosine cap and mediates mRNA binding to the 40S ribosome in the rate limiting step in translational initiation [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 254.0), Brain (RPKM 250.1) and 9 other tissues See more
Orthologs

Genomic context

See Eif4e in Genome Data Viewer
Location:
2q44
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243819616..243853987)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (262354375..262387512)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene methionyl aminopeptidase 1 Neighboring gene uncharacterized LOC102556448 Neighboring gene microRNA 1956 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene uncharacterized LOC102547266

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93265

Gene Ontology Provided by RGD

Function Evidence Code Pubs
RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
 
RNA 7-methylguanosine cap binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
eukaryotic initiation factor 4G binding IPI
Inferred from Physical Interaction
more info
PubMed 
eukaryotic initiation factor 4G binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
repressing transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
translation initiation factor activity TAS
Traceable Author Statement
more info
PubMed 
translation regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
lung development IEP
Inferred from Expression Pattern
more info
PubMed 
NOT negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of translation ISO
Inferred from Sequence Orthology
more info
 
regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of translation at postsynapse, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IEA
Inferred from Electronic Annotation
more info
 
P-body ISO
Inferred from Sequence Orthology
more info
 
RISC complex IEA
Inferred from Electronic Annotation
more info
 
RISC complex ISO
Inferred from Sequence Orthology
more info
 
chromatoid body IEA
Inferred from Electronic Annotation
more info
 
chromatoid body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation initiation factor 4F complex ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
mRNA cap binding complex ISO
Inferred from Sequence Orthology
more info
 
mRNA cap binding complex ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E
Names
eIF-4E
eIF-4F 25 kDa subunit
eukaryotic initiation factor 4E
mRNA cap-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053974.2NP_446426.1  eukaryotic translation initiation factor 4E

    See identical proteins and their annotated locations for NP_446426.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087001
    UniProtKB/Swiss-Prot
    P63074
    Related
    ENSRNOP00000073799.1, OTTRNOP00000002123, ENSRNOT00000090526.2, OTTRNOT00000003690
    Conserved Domains (1) summary
    pfam01652
    Location:38196
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    243819616..243853987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761488.2XP_008759710.1  eukaryotic translation initiation factor 4E isoform X1

    See identical proteins and their annotated locations for XP_008759710.1

    UniProtKB/Swiss-Prot
    P63074
    Conserved Domains (1) summary
    pfam01652
    Location:38196
    IF4E; Eukaryotic initiation factor 4E
  2. XM_017590592.1XP_017446081.1  eukaryotic translation initiation factor 4E isoform X2

    Conserved Domains (1) summary
    pfam01652
    Location:42165
    IF4E; Eukaryotic initiation factor 4E

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    219223372..219255078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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