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Gps1 G protein pathway suppressor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117039, updated on 5-Aug-2018

Summary

Official Symbol
Gps1provided by RGD
Official Full Name
G protein pathway suppressor 1provided by RGD
Primary source
RGD:621532
See related
Ensembl:ENSRNOG00000046698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MFH
Summary
human homolg suppresses G-protein and mitogen-activated protein kinase mediated signal transduction [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 389.1), Testes (RPKM 304.0) and 9 other tissues See more
Orthologs

Genomic context

See Gps1 in Genome Data Viewer
Location:
10q32.3
Exon count:
15
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109966875..109971912)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (109558358..109563402)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27) Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1-like Neighboring gene fatty acid synthase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein deneddylation IEA
Inferred from Electronic Annotation
more info
 
protein deneddylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COP9 signalosome IEA
Inferred from Electronic Annotation
more info
 
COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COP9 signalosome complex subunit 1
Names
GPS-1
JAB1-containing signalosome subunit 1
MFH protein
SGN1
signalosome subunit 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270939.1NP_001257868.1  COP9 signalosome complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_001257868.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, com pared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC061746, CB792560, X87885
    UniProtKB/Swiss-Prot
    P97834
    UniProtKB/TrEMBL
    A0A0G2JW80
    Related
    ENSRNOP00000069778.1, ENSRNOT00000085821.1
    Conserved Domains (2) summary
    pfam01399
    Location:320424
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  2. NM_053969.3NP_446421.3  COP9 signalosome complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_446421.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC061746, CB771566
    UniProtKB/Swiss-Prot
    P97834
    UniProtKB/TrEMBL
    A0A0G2JT06
    Related
    ENSRNOP00000066704.2, ENSRNOT00000071645.2
    Conserved Domains (2) summary
    pfam01399
    Location:359463
    PCI; PCI domain
    pfam10602
    Location:162344
    RPN7; 26S proteasome subunit RPN7

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    109966875..109971912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247867.2XP_006247929.1  COP9 signalosome complex subunit 1 isoform X4

    Conserved Domains (2) summary
    pfam01399
    Location:320424
    PCI; PCI domain
    pfam10602
    Location:123305
    RPN7; 26S proteasome subunit RPN7
  2. XM_008768463.1XP_008766685.1  COP9 signalosome complex subunit 1 isoform X5

    See identical proteins and their annotated locations for XP_008766685.1

    Conserved Domains (2) summary
    pfam01399
    Location:319423
    PCI; PCI domain
    pfam10602
    Location:123304
    RPN7; 26S proteasome subunit RPN7
  3. XM_006247865.1XP_006247927.1  COP9 signalosome complex subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam01399
    Location:359463
    PCI; PCI domain
    pfam10602
    Location:162344
    RPN7; 26S proteasome subunit RPN7
  4. XM_006247866.1XP_006247928.1  COP9 signalosome complex subunit 1 isoform X2

    Conserved Domains (2) summary
    pfam01399
    Location:358462
    PCI; PCI domain
    pfam10602
    Location:162343
    RPN7; 26S proteasome subunit RPN7
  5. XM_008768462.1XP_008766684.1  COP9 signalosome complex subunit 1 isoform X3

    See identical proteins and their annotated locations for XP_008766684.1

    Conserved Domains (2) summary
    pfam01399
    Location:358462
    PCI; PCI domain
    pfam10602
    Location:162343
    RPN7; 26S proteasome subunit RPN7

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    104594178..104599186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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