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Mt3 metallothionein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117038, updated on 9-Oct-2021

Summary

Official Symbol
Mt3provided by RGD
Official Full Name
metallothionein 3provided by RGD
Primary source
RGD:621252
See related
EnsemblRapid:ENSRNOG00000018958
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GIF; Mt-3
Summary
heavy metal binding protein; acts as an inhibitor of neurite sprouting and deficiency may play a role in Alzheimer's disease [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 2235.4), Testes (RPKM 255.5) and 1 other tissue See more
Orthologs
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Genomic context

See Mt3 in Genome Data Viewer
Location:
19p12
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10848754..10850158, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (11324708..11326112, complement)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene metallothionein 1 Neighboring gene metallothionein 2A Neighboring gene metallothionein 4 Neighboring gene uncharacterized LOC108348893 Neighboring gene Bardet-Biedl syndrome 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cadmium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables cadmium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase B activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cadmium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cadmium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular metal ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cadmium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nitric oxide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cholesterol catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in energy reserve metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in histone modification ISO
Inferred from Sequence Orthology
more info
 
involved_in histone modification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leptin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of dendrite morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necrotic cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lysosomal membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lysosomal membrane permeability ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necrotic cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of oxygen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxygen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of response to food ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to food ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
involved_in removal of superoxide radicals ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in zinc ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in astrocyte end-foot IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
metallothionein-3
Names
MT-III
growth inhibitory factor
metallothionein III

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053968.3NP_446420.1  metallothionein-3

    See identical proteins and their annotated locations for NP_446420.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058453
    UniProtKB/Swiss-Prot
    P37361
    Related
    ENSRNOP00000025669.3, ENSRNOT00000025669.6
    Conserved Domains (1) summary
    pfam00131
    Location:166
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    10848754..10850158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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