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Amd1 S-adenosylmethionine decarboxylase 1 [ Mus musculus (house mouse) ]

Gene ID: 11702, updated on 26-Sep-2022

Summary

Official Symbol
Amd1provided by MGI
Official Full Name
S-adenosylmethionine decarboxylase 1provided by MGI
Primary source
MGI:MGI:88004
See related
Ensembl:ENSMUSG00000075232 AllianceGenome:MGI:88004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amd-1; SAMDC; SAMDC 1; AdoMetDC; adoMetDC1
Summary
Enables adenosylmethionine decarboxylase activity. Acts upstream of or within in utero embryonic development; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; cranium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 38.2), liver E14 (RPKM 34.2) and 24 other tissues See more
Orthologs
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Genomic context

See Amd1 in Genome Data Viewer
Location:
10 B1; 10 21.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40163454..40178184, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40287458..40302188, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIIC, polypeptide 6, alpha Neighboring gene small nucleolar RNA, C/D box 3A Neighboring gene predicted gene 8948 Neighboring gene cyclin-dependent kinase 19 Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC91044, MGC102468

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenosylmethionine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenosylmethionine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables putrescine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables putrescine binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in S-adenosylmethionine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in polyamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermidine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in spermine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
S-adenosylmethionine decarboxylase proenzyme 1
Names
adoMetDC 1
NP_033795.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009665.5NP_033795.1  S-adenosylmethionine decarboxylase proenzyme 1

    See identical proteins and their annotated locations for NP_033795.1

    Status: VALIDATED

    Source sequence(s)
    AC142273, AK146840
    Consensus CDS
    CCDS48544.1
    UniProtKB/Swiss-Prot
    P0DMN7, Q58E47
    Related
    ENSMUSP00000159133.2, ENSMUST00000238969.2
    Conserved Domains (1) summary
    pfam01536
    Location:4325
    SAM_decarbox; Adenosylmethionine decarboxylase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    40163454..40178184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)