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Kcnh2 potassium voltage-gated channel subfamily H member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117018, updated on 12-Jan-2022

Summary

Official Symbol
Kcnh2provided by RGD
Official Full Name
potassium voltage-gated channel subfamily H member 2provided by RGD
Primary source
RGD:621414
See related
Ensembl:ENSRNOG00000009872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ERG1
Summary
Enables inward rectifier potassium channel activity and scaffold protein binding activity. Involved in central nervous system development; potassium ion transport; and regulation of membrane potential. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 93.7), Thymus (RPKM 61.9) and 8 other tissues See more
Orthologs
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Genomic context

See Kcnh2 in Genome Data Viewer
Location:
4q11
Exon count:
18
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10826834..10859009)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7355066..7387282)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102208 Neighboring gene autophagy related 9B Neighboring gene nitric oxide synthase 3 Neighboring gene uncharacterized LOC108350647 Neighboring gene uncharacterized LOC102554730 Neighboring gene nucleoporin like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C3HC4-type RING finger domain binding IEA
Inferred from Electronic Annotation
more info
 
enables C3HC4-type RING finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane repolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during ventricular cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane repolarization during ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of inward rectifier potassium channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of inward rectifier potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily H member 2
Names
ERG-1
RERG
eag-related protein 1
ether-a-go-go-related gene potassium channel 1
ether-a-go-go-related protein 1
potassium channel, voltage gated eag related subfamily H, member 2
potassium voltage-gated channel, subfamily H (eag-related), member 2
r-ERG
voltage-gated potassium channel subunit Kv11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053949.1NP_446401.1  potassium voltage-gated channel subfamily H member 2

    See identical proteins and their annotated locations for NP_446401.1

    Status: PROVISIONAL

    Source sequence(s)
    Z96106
    UniProtKB/Swiss-Prot
    O08962
    Related
    ENSRNOP00000013800.3, ENSRNOT00000013800.5
    Conserved Domains (7) summary
    COG0664
    Location:738858
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:744855
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:451670
    Ion_trans; Ion transport protein
    pfam07885
    Location:613667
    Ion_trans_2; Ion channel
    pfam13426
    Location:29130
    PAS_9; PAS domain
    pfam15836
    Location:10161117
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    10826834..10859009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235867.4XP_006235929.2  potassium voltage-gated channel subfamily H member 2 isoform X1

  2. XM_039106951.1XP_038962879.1  potassium voltage-gated channel subfamily H member 2 isoform X4

    Conserved Domains (3) summary
    PHA03307
    Location:211379
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:482722
    Ion_trans; Ion transport protein
    pfam13426
    Location:100201
    PAS_9; PAS domain
  3. XM_039106950.1XP_038962878.1  potassium voltage-gated channel subfamily H member 2 isoform X2

    Conserved Domains (3) summary
    PHA03307
    Location:104185
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00038
    Location:621732
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:288547
    Ion_trans; Ion transport protein
  4. XM_008762630.3XP_008760852.1  potassium voltage-gated channel subfamily H member 2 isoform X3

    See identical proteins and their annotated locations for XP_008760852.1

    UniProtKB/TrEMBL
    Q6DKY7
    Related
    ENSRNOP00000073593.1, ENSRNOT00000084826.2
    Conserved Domains (5) summary
    COG0664
    Location:396516
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:402513
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:109328
    Ion_trans; Ion transport protein
    pfam07885
    Location:271325
    Ion_trans_2; Ion channel
    pfam15836
    Location:674775
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
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