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Il16 interleukin 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116996, updated on 27-Sep-2025
Official Symbol
Il16provided by RGD
Official Full Name
interleukin 16provided by RGD
Primary source
RGD:1583872
See related
Ensembl:ENSRNOG00000011680 AllianceGenome:RGD:1583872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable CD4 receptor binding activity and cytokine activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of inflammatory response. Predicted to act upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Predicted to be located in several cellular components, including Flemming body; focal adhesion; and nuclear speck. Biomarker of borna disease; glioblastoma; and periodontal disease. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Thymus (RPKM 123.3), Spleen (RPKM 109.1) and 8 other tissues See more
Orthologs
human mouse all
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See Il16 in Genome Data Viewer
Location:
1q31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (147026852..147127177, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (137617702..137718022, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (145781923..145881538, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like 3 Neighboring gene StAR-related lipid transfer domain containing 5 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 10 Neighboring gene cilia and flagella associated protein 161 Neighboring gene ring finger and CHY zinc finger domain containing 1, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81. Luo Z, et al. Cartilage, 2024 Jun. PMID 37086007, Free PMC Article
  2. A fusion protein consisting of IL-16 and the encephalitogenic peptide of myelin basic protein constitutes an antigen-specific tolerogenic vaccine that inhibits experimental autoimmune encephalomyelitis. Mannie MD, et al. J Immunol, 2007 Aug 1. PMID 17641011
  3. Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury. Zhang Z, et al. Neuropathol Appl Neurobiol, 2008 Jun. PMID 17983426
  4. Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model. de Bie JJ, et al. Eur J Pharmacol, 1999 Oct 27. PMID 10585533
  5. [Effect of fluticasone inhalation combined with xiaoqinglong decoction on pulmonary function and serum interleukin-16 level in asthma patients]. Zhang X, et al. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003 Jun. PMID 12872394

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81.
    Title: IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81.
  2. p21WAF1 was required for the induction of p38MAPK-mediated MMP-9 expression via activation of the Sp-1 binding motif, which led to migration and invasion of vascular smooth muscle cells interacting with IL-16/CD4.
    Title: p21WAF1 Is Required for Interleukin-16-Induced Migration and Invasion of Vascular Smooth Muscle Cells via the p38MAPK/Sp-1/MMP-9 Pathway.
  3. Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
    Title: Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
  4. taken together, robust IL-16+ cell accumulation in the nervous system and its temporal correlation with severity of neurological signs in experimental autoimmune neuritis (EAN might suggest a pathological role of IL-16 in EAN
    Title: Expression of interleukin-16 in sciatic nerves, spinal roots and spinal cords of experimental autoimmune neuritis rats.
  5. IL-16 immunoreactivity is a putative marker of a monocytic subset in rat gliomas in vivo and may be a novel factor in the regulation of the local inflammatory milieu and tumor progression.
    Title: Expression of interleukin-16 by tumor-associated macrophages/activated microglia in high-grade astrocytic brain tumors.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CD4 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 alpha production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neutrophil activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
pro-interleukin-16

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105749.2 → NP_001099219.1  pro-interleukin-16 isoform 1

    See identical proteins and their annotated locations for NP_001099219.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JCM5, D4A4I9
    Related
    ENSRNOP00000016289.5, ENSRNOT00000016289.6
    Conserved Domains (2) summary
    smart00228
    Location:1227 → 1311
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1105 → 1182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001443579.1 → NP_001430508.1  pro-interleukin-16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_001443581.1 → NP_001430510.1  pro-interleukin-16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  4. NM_001443582.1 → NP_001430511.1  pro-interleukin-16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  5. NM_001443583.1 → NP_001430512.1  pro-interleukin-16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    147026852..147127177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588676.3 → XP_017444165.1  pro-interleukin-16 isoform X5

    Related
    ENSRNOP00000104773.1, ENSRNOT00000165706.1

  2. XM_017588678.3 → XP_017444167.1  pro-interleukin-16 isoform X6

  3. XM_017588673.3 → XP_017444162.1  pro-interleukin-16 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZI8
    Related
    ENSRNOP00000083582.1, ENSRNOT00000101175.2

  4. XM_063266338.1 → XP_063122408.1  pro-interleukin-16 isoform X4

    UniProtKB/TrEMBL
    A6JCM5, D4A4I9

  5. XM_017588675.3 → XP_017444164.1  pro-interleukin-16 isoform X3

    Related
    ENSRNOP00000109090.1, ENSRNOT00000153733.1

  6. XM_008759600.4 → XP_008757822.1  pro-interleukin-16 isoform X4

    UniProtKB/TrEMBL
    A6JCM5, D4A4I9
    Conserved Domains (2) summary
    smart00228
    Location:1227 → 1311
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1105 → 1182
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  7. XM_006229488.5 → XP_006229550.1  pro-interleukin-16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AF93
    Related
    ENSRNOP00000091335.1, ENSRNOT00000101850.2
    Conserved Domains (2) summary
    smart00228
    Location:1329 → 1413
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1207 → 1284
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  8. XM_039112275.2 → XP_038968203.1  pro-interleukin-16 isoform X7

    Conserved Domains (1) summary
    cd00992
    Location:294 → 369
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein Strain
Heading Accession and Version

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