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ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [ Homo sapiens (human) ]

Gene ID: 116983, updated on 15-Apr-2019

Summary

Official Symbol
ACAP3provided by HGNC
Official Full Name
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3provided by HGNC
Primary source
HGNC:HGNC:16754
See related
Ensembl:ENSG00000131584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENTB5
Expression
Ubiquitous expression in skin (RPKM 16.2), brain (RPKM 12.8) and 24 other tissues See more
Orthologs

Genomic context

See ACAP3 in Genome Data Viewer
Location:
1p36.33
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1292384..1307925, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1227764..1243304, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1786 Neighboring gene sodium channel epithelial 1 delta subunit Neighboring gene CEB15 minisatellite repeat instability region Neighboring gene microRNA 6726 Neighboring gene small nucleolar RNA, C/D box 167 Neighboring gene pseudouridine synthase like 1 Neighboring gene integrator complex subunit 11 Neighboring gene microRNA 6727

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1716

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
neuron migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
growth cone IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
Names
centaurin-beta-5
cnt-b5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030649.3NP_085152.2  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

    See identical proteins and their annotated locations for NP_085152.2

    Status: VALIDATED

    Source sequence(s)
    AB051503, AL139287, BC051194
    Consensus CDS
    CCDS19.2
    UniProtKB/Swiss-Prot
    Q96P50
    UniProtKB/TrEMBL
    Q8WTZ1
    Related
    ENSP00000346733.5, ENST00000354700.10
    Conserved Domains (7) summary
    cd07637
    Location:16215
    BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
    cd00204
    Location:701788
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:271367
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:269363
    PH; PH domain
    pfam01412
    Location:403521
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:705756
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:702733
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    1292384..1307925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244715.2XP_005244772.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X6

    Related
    ENSP00000321139.4, ENST00000353662.4
    Conserved Domains (7) summary
    cd00204
    Location:668755
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:271367
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:269363
    PH; PH domain
    pfam01412
    Location:403521
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:672723
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:669700
    ANK; ANK repeat [structural motif]
    cl12013
    Location:16215
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_011540608.2XP_011538910.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X4

    Conserved Domains (7) summary
    cd00204
    Location:679766
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:249345
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:247341
    PH; PH domain
    pfam01412
    Location:381499
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:683734
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:680711
    ANK; ANK repeat [structural motif]
    cl12013
    Location:16200
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_011540609.2XP_011538911.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X5

    Conserved Domains (7) summary
    cd00204
    Location:678765
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:281377
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:279373
    PH; PH domain
    pfam01412
    Location:413531
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:682733
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:679710
    ANK; ANK repeat [structural motif]
    cl12013
    Location:16225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_011540606.2XP_011538908.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

    Conserved Domains (7) summary
    cd00204
    Location:711798
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:281377
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:279373
    PH; PH domain
    pfam01412
    Location:413531
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:715766
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:712743
    ANK; ANK repeat [structural motif]
    cl12013
    Location:16225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. XM_017000233.1XP_016855722.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X7

  6. XM_024452993.1XP_024308761.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X3

    Conserved Domains (5) summary
    cd07637
    Location:16215
    BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
    cd00204
    Location:701788
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:271367
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:702733
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:403521
    ArfGap; Putative GTPase activating protein for Arf
  7. XM_011540607.1XP_011538909.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X2

    Conserved Domains (7) summary
    cd00204
    Location:711798
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:281377
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:279373
    PH; PH domain
    pfam01412
    Location:413531
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:715766
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:712743
    ANK; ANK repeat [structural motif]
    cl12013
    Location:16225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  8. XM_005244717.3XP_005244774.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X8

    Conserved Domains (5) summary
    cd00204
    Location:360447
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01412
    Location:62180
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:364415
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:361392
    ANK; ANK repeat [structural motif]
    cl17171
    Location:126
    PH-like; Pleckstrin homology-like domain
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