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MED12L mediator complex subunit 12L [ Homo sapiens (human) ]

Gene ID: 116931, updated on 31-Jul-2021

Summary

Official Symbol
MED12Lprovided by HGNC
Official Full Name
mediator complex subunit 12Lprovided by HGNC
Primary source
HGNC:HGNC:16050
See related
Ensembl:ENSG00000144893 MIM:611318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOPAR; TRALP; NIZIDS; TNRC11L; TRALPUSH
Summary
The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Expression
Broad expression in testis (RPKM 2.2), brain (RPKM 1.5) and 18 other tissues See more
Orthologs
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Genomic context

See MED12L in Genome Data Viewer
Location:
3q25.1
Exon count:
49
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151085664..151436653)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150804585..151154465)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9248 Neighboring gene clarin 1 Neighboring gene CLRN1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 145 Neighboring gene G protein-coupled receptor 171 Neighboring gene purinergic receptor P2Y14 Neighboring gene SET pseudogene 11 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13 Neighboring gene purinergic receptor P2Y12 Neighboring gene immunoglobulin superfamily member 10 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 6 Neighboring gene microRNA 5186

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
GeneReviews: Not available
Gene network analysis in a pediatric cohort identifies novel lung function genes.
GeneReviews: Not available
Nizon-Isidor syndrome
MedGen: C5394350 OMIM: 618872 GeneReviews: Not available
not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46288, KIAA1635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 12-like protein
Names
mediator complex subunit 12 like
mediator of RNA polymerase II transcription, subunit 12 homolog-like
no opposite paired repeat protein
thyroid hormone receptor-associated-like protein
trinucleotide repeat-containing gene 11 protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021244.1 RefSeqGene

    Range
    4910..354790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393769.1NP_001380698.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC024886, AC078816, AC108726
    Conserved Domains (3) summary
    pfam09497
    Location:106161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18372054
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  2. NM_053002.6NP_443728.3  mediator of RNA polymerase II transcription subunit 12-like protein isoform 2

    See identical proteins and their annotated locations for NP_443728.3

    Status: VALIDATED

    Source sequence(s)
    AC024886, AC078816, AC108726, AF399708, AK128165
    Consensus CDS
    CCDS33876.1
    UniProtKB/Swiss-Prot
    Q86YW9
    UniProtKB/TrEMBL
    B3KXY0
    Related
    ENSP00000417235.1, ENST00000474524.5
    Conserved Domains (3) summary
    pfam09497
    Location:103161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18032016
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283730
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151085664..151436653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005676.1XP_016861165.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

  2. XM_017005678.1XP_016861167.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

  3. XM_017005677.1XP_016861166.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

  4. XM_017005680.1XP_016861169.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

  5. XM_017005679.1XP_016861168.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

  6. XM_011512394.2XP_011510696.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

    Conserved Domains (2) summary
    pfam09497
    Location:103161
    Med12; Transcription mediator complex subunit Med12
    pfam12145
    Location:283765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  7. XM_011512399.3XP_011510701.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

    Conserved Domains (2) summary
    pfam09497
    Location:103161
    Med12; Transcription mediator complex subunit Med12
    pfam12145
    Location:283765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  8. XM_017005681.1XP_016861170.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

RNA

  1. XR_001740000.1 RNA Sequence

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