Calcb calcitonin-related polypeptide, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calcbprovided by MGI
Official Full Name: calcitonin-related polypeptide, betaprovided by MGI
Primary source: MGI:MGI:2151254
See related: Ensembl:ENSMUSG00000030666 AllianceGenome:MGI:2151254
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CGRP2; Calc2
Summary: Predicted to enable calcitonin receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cytosolic calcium ion concentration. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human CALCB (calcitonin related polypeptide beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 2.1), large intestine adult (RPKM 0.5) and 13 other tissues See more
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Genomic context

Location:: 7; 7 F1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (114315790..114322603)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (114716555..114723368)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

activation of periosteal mineralizing surfaces in response to mechanical loading of bone is CGRPalpha-dependent in vivo.
Title: Role of calcitonin gene-related peptide in functional adaptation of the skeleton.
gene expression of calcitonin gene-related peptide beta in mouse brain, liver, kidney, heart, & testis at embryonic day 14, 17, postnatal day 1, 7, and adult. found mainly in brain. one expression peak at E17, the other at P7. also C cells of e17 thyroid.
Title: alphaCGRP and betaCGRP transcript amount in mouse tissues of various developmental stages and their tissue expression sites.
A close association of betaCGRP-containing dysmorphic dendritic structures with processes of activated astrocytes suggests that betaCGRP may function as a motor neuron-derived signaling molecule for astrocyte activation in amyotrophic lateral sclerosis
Title: Pre-symptomatic alterations in subcellular betaCGRP distribution in motor neurons precede astrogliosis in ALS mice.
These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells.
Title: Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcitonin receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: calcitonin gene-related peptide 2

Names: CGRP-II; beta-type CGRP; calcitonin gene-related peptide II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.