U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Alox8 arachidonate 8-lipoxygenase [ Mus musculus (house mouse) ]

Gene ID: 11688, updated on 5-Jan-2023

Summary

Official Symbol
Alox8provided by MGI
Official Full Name
arachidonate 8-lipoxygenaseprovided by MGI
Primary source
MGI:MGI:1098228
See related
Ensembl:ENSMUSG00000020891 AllianceGenome:MGI:1098228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8-LOX; 8S-LOX; Alox15b; 15-LOX-2; 15-LOX-B
Summary
This gene belongs to the lipoxygenase (LOX) gene family whose members encode enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acids (PUFAs) to yield fatty acid hydroperoxides. The encoded enzyme preferentially metabolizes arachidonic acid to yield 8-hydroxyeicosatetraenoic acid (8-HETE), while metabolizing linoleic acid less efficiently. The gene may also function as a tumor suppressor. This gene is located in a cluster of related genes that spans approximately 75 kilobases on chromosome 11. [provided by RefSeq, Jan 2013]
Expression
Biased expression in cerebellum adult (RPKM 1.1), cortex adult (RPKM 0.5) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Alox8 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69074711..69088669, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69183885..69197843, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene arachidonate lipoxygenase 3 Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene guanylate cyclase 2e Neighboring gene predicted gene, 23194

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate 15-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate 15-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonate 8(R)-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables arachidonate 8(S)-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables linoleate 13S-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables linoleate 9S-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cannabinoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in endocannabinoid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipoxin A4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX8
Names
15-lipoxygenase 2
8S-lipoxygenase
arachidonate 15-lipoxygenase B
arachidonate 15-lipoxygenase type II
arachidonate 15-lipoxygenase, second type
arachidonate 8S-lipoxygenase
linoleate 9S-lipoxygenase ALOX8
NP_033791.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009661.4NP_033791.1  polyunsaturated fatty acid lipoxygenase ALOX8

    See identical proteins and their annotated locations for NP_033791.1

    Status: REVIEWED

    Source sequence(s)
    AK028724, AL645527
    Consensus CDS
    CCDS24886.1
    UniProtKB/Swiss-Prot
    B1ASX5, O35936
    Related
    ENSMUSP00000021262.4, ENSMUST00000021262.10
    Conserved Domains (2) summary
    cd01753
    Location:5122
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:230668
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69074711..69088669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)