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Serpinb7 serine (or cysteine) peptidase inhibitor, clade B, member 7 [ Mus musculus (house mouse) ]

Gene ID: 116872, updated on 13-Oct-2022

Summary

Official Symbol
Serpinb7provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 7provided by MGI
Primary source
MGI:MGI:2151053
See related
Ensembl:ENSMUSG00000067001 AllianceGenome:MGI:2151053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
megsin; ovalbumin; 4631416M05Rik
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including positive regulation of collagen biosynthetic process; positive regulation of cytokine production; and positive regulation of glomerular mesangial cell proliferation. Predicted to act upstream of or within regulation of proteolysis. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINB7 (serpin family B member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Serpinb7 in Genome Data Viewer
Location:
1; 1 E2.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (107350419..107380419)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107422689..107452689)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8089 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11 Neighboring gene predicted gene, 24553 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 2 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 Neighboring gene SCAN domain containing 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

General protein information

Preferred Names
serpin B7
Names
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7
serine (or cysteine) proteinase inhibitor, clade B, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027548.4NP_081824.1  serpin B7

    See identical proteins and their annotated locations for NP_081824.1

    Status: VALIDATED

    Source sequence(s)
    AC129295, AC148982
    Consensus CDS
    CCDS35686.1
    UniProtKB/Swiss-Prot
    Q9D695
    UniProtKB/TrEMBL
    Q6P3F8
    Related
    ENSMUSP00000083896.5, ENSMUST00000086690.6
    Conserved Domains (1) summary
    cl00137
    Location:4380
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    107350419..107380419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)