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Mta3 metastasis associated 3 [ Mus musculus (house mouse) ]

Gene ID: 116871, updated on 11-Jun-2024

Summary

Official Symbol
Mta3provided by MGI
Official Full Name
metastasis associated 3provided by MGI
Primary source
MGI:MGI:2151172
See related
Ensembl:ENSMUSG00000055817 AllianceGenome:MGI:2151172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1266; 1110002J22Rik
Summary
Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle and positive regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in brain; early conceptus; genitourinary system; and limb. Orthologous to human MTA3 (metastasis associated 1 family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 8.8), cerebellum adult (RPKM 8.0) and 28 other tissues See more
Orthologs
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Genomic context

See Mta3 in Genome Data Viewer
Location:
17 E4; 17 54.53 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84013483..84131144)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (83706163..83823715)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34801 Neighboring gene potassium voltage-gated channel, subfamily G, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E9967 Neighboring gene STARR-seq mESC enhancer starr_43388 Neighboring gene STARR-seq mESC enhancer starr_43389 Neighboring gene STARR-seq mESC enhancer starr_43390 Neighboring gene STARR-seq mESC enhancer starr_43391 Neighboring gene STARR-seq mESC enhancer starr_43393 Neighboring gene predicted gene, 46597 Neighboring gene STARR-seq mESC enhancer starr_43408 Neighboring gene predicted gene, 41637 Neighboring gene 3-hydroxyanthranilate 3,4-dioxygenase Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metastasis-associated protein MTA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171052.1NP_001164523.1  metastasis-associated protein MTA3 isoform 1

    See identical proteins and their annotated locations for NP_001164523.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC155160, AK146905
    Consensus CDS
    CCDS50196.1
    UniProtKB/TrEMBL
    Q3UII8, Q3UKM9
    Related
    ENSMUSP00000107971.4, ENSMUST00000112352.10
    Conserved Domains (6) summary
    smart00717
    Location:269316
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375426
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:377425
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
  2. NM_001171053.1NP_001164524.1  metastasis-associated protein MTA3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the middle portion of the coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC155160, AK147197, BU756693, CA751287
    Consensus CDS
    CCDS50195.1
    UniProtKB/TrEMBL
    E9Q794, Q3UKM9
    Related
    ENSMUSP00000107968.3, ENSMUST00000112349.9
    Conserved Domains (6) summary
    smart00717
    Location:269316
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376427
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:378426
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
  3. NM_001171054.1NP_001164525.1  metastasis-associated protein MTA3 isoform 4

    See identical proteins and their annotated locations for NP_001164525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC155160, AK147197, BU756693
    Consensus CDS
    CCDS50197.1
    UniProtKB/TrEMBL
    Q3U3A7, Q3UKM9
    Related
    ENSMUSP00000107969.2, ENSMUST00000112350.8
    Conserved Domains (6) summary
    smart00717
    Location:269316
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375426
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:377425
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
  4. NM_001379388.1NP_001366317.1  metastasis-associated protein MTA3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC155160, AC155636
    UniProtKB/TrEMBL
    Q3UKM9
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376427
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:460536
    MTA_R1; MTA R1 domain
  5. NM_001379389.1NP_001366318.1  metastasis-associated protein MTA3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC155160, AC155636
    UniProtKB/TrEMBL
    Q3UKM9
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376427
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:460536
    MTA_R1; MTA R1 domain
  6. NM_001379390.1NP_001366319.1  metastasis-associated protein MTA3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC155160, AC155636
    UniProtKB/TrEMBL
    Q3UKM9
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375426
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:459535
    MTA_R1; MTA R1 domain
  7. NM_001379391.1NP_001366320.1  metastasis-associated protein MTA3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC155160, AC155636
    UniProtKB/TrEMBL
    Q3UKM9
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375426
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:459535
    MTA_R1; MTA R1 domain
  8. NM_001379392.1NP_001366321.1  metastasis-associated protein MTA3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC155160, AC155636
    UniProtKB/TrEMBL
    Q3UKM9
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376427
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:460536
    MTA_R1; MTA R1 domain
  9. NM_054082.2NP_473423.1  metastasis-associated protein MTA3 isoform 2

    See identical proteins and their annotated locations for NP_473423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC155160, AC155636, AK146905
    Consensus CDS
    CCDS28997.1
    UniProtKB/Swiss-Prot
    Q8VC18, Q924K8
    UniProtKB/TrEMBL
    Q3UKM9
    Related
    ENSMUSP00000068931.9, ENSMUST00000067826.15
    Conserved Domains (6) summary
    smart00717
    Location:268315
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:269314
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:374425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:376424
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150200
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    84013483..84131144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523511.3XP_006523574.1  metastasis-associated protein MTA3 isoform X4

    UniProtKB/TrEMBL
    Q3TY62
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376427
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:460536
    MTA_R1; MTA R1 domain
  2. XM_006523506.2XP_006523569.1  metastasis-associated protein MTA3 isoform X1

    UniProtKB/TrEMBL
    Q3TY62
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375426
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:459535
    MTA_R1; MTA R1 domain
  3. XM_006523509.4XP_006523572.1  metastasis-associated protein MTA3 isoform X2

    UniProtKB/TrEMBL
    Q3UKM9
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376427
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:460536
    MTA_R1; MTA R1 domain
  4. XM_036160270.1XP_036016163.1  metastasis-associated protein MTA3 isoform X3

    UniProtKB/TrEMBL
    Q3UKM9
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375426
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:459535
    MTA_R1; MTA R1 domain