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Prelp proline arginine-rich end leucine-rich repeat [ Mus musculus (house mouse) ]

Gene ID: 116847, updated on 13-Nov-2022

Summary

Official Symbol
Prelpprovided by MGI
Official Full Name
proline arginine-rich end leucine-rich repeatprovided by MGI
Primary source
MGI:MGI:2151110
See related
Ensembl:ENSMUSG00000041577 AllianceGenome:MGI:2151110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SLRR2A; 7330409J17Rik
Summary
Predicted to enable heparin binding activity. Acts upstream of or within cell aging. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; connective tissue; eye; nervous system; and reproductive system. Orthologous to human PRELP (proline and arginine rich end leucine rich repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 99.9), lung adult (RPKM 77.1) and 15 other tissues See more
Orthologs
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Genomic context

See Prelp in Genome Data Viewer
Location:
1 E4; 1 58.02 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133838042..133857820, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133910304..133930102, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31515 Neighboring gene opticin Neighboring gene bone marrow associated noncoding RNA Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
prolargin
Names
proline-arginine-rich end leucine-rich repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054077.4NP_473418.3  prolargin precursor

    See identical proteins and their annotated locations for NP_473418.3

    Status: VALIDATED

    Source sequence(s)
    AK037150, AK047480
    Consensus CDS
    CCDS15300.1
    UniProtKB/Swiss-Prot
    Q9JK53
    UniProtKB/TrEMBL
    Q543S0, Q8CAZ9
    Related
    ENSMUSP00000048803.6, ENSMUST00000048432.6
    Conserved Domains (3) summary
    PRK15370
    Location:129349
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00013
    Location:68103
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:100123
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133838042..133857820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529084.5XP_006529147.1  prolargin isoform X1

    See identical proteins and their annotated locations for XP_006529147.1

    UniProtKB/Swiss-Prot
    Q9JK53
    UniProtKB/TrEMBL
    Q543S0
    Conserved Domains (3) summary
    PRK15370
    Location:129349
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00013
    Location:68103
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:100123
    LRR_RI; leucine-rich repeat [structural motif]