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LRG1 leucine rich alpha-2-glycoprotein 1 [ Homo sapiens (human) ]

Gene ID: 116844, updated on 25-Sep-2022

Summary

Official Symbol
LRG1provided by HGNC
Official Full Name
leucine rich alpha-2-glycoprotein 1provided by HGNC
Primary source
HGNC:HGNC:29480
See related
Ensembl:ENSG00000171236 MIM:611289; AllianceGenome:HGNC:29480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRG; HMFT1766
Summary
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in liver (RPKM 150.7), esophagus (RPKM 16.6) and 4 other tissues See more
Orthologs
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Genomic context

See LRG1 in Genome Data Viewer
Location:
19p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4536402..4540036, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4520069..4523703, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4536414..4540048, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene semaphorin 6B Neighboring gene Sharpr-MPRA regulatory region 7851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4567569-4568069

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PLIN5

Homology

Clone Names

  • FLJ45787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type I transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type II transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
leucine-rich alpha-2-glycoprotein
Names
1300008B03Rik
2310031E04Rik
leucine rich alpha 2 glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052972.3NP_443204.1  leucine-rich alpha-2-glycoprotein precursor

    See identical proteins and their annotated locations for NP_443204.1

    Status: VALIDATED

    Source sequence(s)
    AC011498, AF403428, AK027382
    Consensus CDS
    CCDS12130.1
    UniProtKB/Swiss-Prot
    P02750, Q96QZ4
    UniProtKB/TrEMBL
    Q68CK4
    Related
    ENSP00000302621.4, ENST00000306390.7
    Conserved Domains (4) summary
    smart00082
    Location:299346
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:82248
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:94117
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:116176
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4536402..4540036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4520069..4523703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)