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SLC18B1 solute carrier family 18 member B1 [ Homo sapiens (human) ]

Gene ID: 116843, updated on 23-Sep-2022

Summary

Official Symbol
SLC18B1provided by HGNC
Official Full Name
solute carrier family 18 member B1provided by HGNC
Primary source
HGNC:HGNC:21573
See related
Ensembl:ENSG00000146409 MIM:613361; AllianceGenome:HGNC:21573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf192; dJ55C23.6
Summary
This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 13.1), duodenum (RPKM 8.9) and 25 other tissues See more
Orthologs
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Genomic context

See SLC18B1 in Genome Data Viewer
Location:
6q23.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132769370..132798637, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133964359..133993657, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (133090509..133119776, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene vanin 2 Neighboring gene RNA binding motif protein 11 pseudogene 1 Neighboring gene uncharacterized LOC107986644 Neighboring gene small nucleolar RNA, C/D box 101 Neighboring gene ribosomal protein S12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monoamine:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables polyamine:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in serotonin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermidine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermine transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
MFS-type transporter SLC18B1
Names
MFS-type transporter C6orf192
solute carrier family 18, subfamily B, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052831.3NP_439896.1  MFS-type transporter SLC18B1

    See identical proteins and their annotated locations for NP_439896.1

    Status: VALIDATED

    Source sequence(s)
    AK124442, AL137783, BC069570, CB218467, CD635228
    Consensus CDS
    CCDS5163.1
    UniProtKB/Swiss-Prot
    Q6ISF2, Q6NT16
    Related
    ENSP00000275227.4, ENST00000275227.9
    Conserved Domains (2) summary
    cd06174
    Location:37426
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:41392
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132769370..132798637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418165.1XP_047274121.1  MFS-type transporter SLC18B1 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT67
    Related
    ENSP00000497768.1, ENST00000647932.1
  2. XM_047418166.1XP_047274122.1  MFS-type transporter SLC18B1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133964359..133993657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)