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Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) [ Mus musculus (house mouse) ]

Gene ID: 11677, updated on 8-Nov-2022

Summary

Official Symbol
Akr1b3provided by MGI
Official Full Name
aldo-keto reductase family 1, member B3 (aldose reductase)provided by MGI
Primary source
MGI:MGI:1353494
See related
Ensembl:ENSMUSG00000001642 AllianceGenome:MGI:1353494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b1; Aldor1
Summary
Enables alditol:NADP+ 1-oxidoreductase activity. Acts upstream of or within several processes, including epithelial cell maturation; metanephric collecting duct development; and renal water homeostasis. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 290.1), heart adult (RPKM 93.4) and 24 other tissues See more
Orthologs
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Genomic context

See Akr1b3 in Genome Data Viewer
Location:
6 14.87 cM; 6 B1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34280865..34294424, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34303930..34317489, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member B4 Neighboring gene predicted gene 13855 Neighboring gene predicted gene, 32533 Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene cancer susceptibility candidate 4 pseudogene Neighboring gene RIO kinase 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-glucuronate reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADP-retinol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables alditol:NADP+ 1-oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alditol:NADP+ 1-oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alditol:NADP+ 1-oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables alditol:NADP+ 1-oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables allyl-alcohol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables glyceraldehyde oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-ascorbic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular hyperosmotic salinity response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to methylglyoxal ISO
Inferred from Sequence Orthology
more info
 
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fructose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner medullary collecting duct development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in organic cyclic compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of urine volume IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within renal water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to water deprivation ISO
Inferred from Sequence Orthology
more info
 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sorbitol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
 
located_in Schwann cell microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mast cell granule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in paranodal junction ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane bounded cell projection cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aldo-keto reductase family 1 member B1
Names
aldehyde reductase 1
aldo-keto reductase family 1 member B3
aldo-keto reductase family 1, member B1 (aldose reductase)
aldose reductase
NP_033788.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009658.3NP_033788.3  aldo-keto reductase family 1 member B1

    See identical proteins and their annotated locations for NP_033788.3

    Status: VALIDATED

    Source sequence(s)
    AK164682, AV301527, BY749711
    Consensus CDS
    CCDS19990.1
    UniProtKB/Swiss-Prot
    P45376, Q99KC9
    UniProtKB/TrEMBL
    Q3UDY1
    Related
    ENSMUSP00000100045.5, ENSMUST00000102980.11
    Conserved Domains (2) summary
    COG0656
    Location:1297
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:8289
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34280865..34294424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)