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Lsm10 U7 snRNP-specific Sm-like protein LSM10 [ Mus musculus (house mouse) ]

Gene ID: 116748, updated on 27-Nov-2024

Summary

Official Symbol
Lsm10provided by MGI
Official Full Name
U7 snRNP-specific Sm-like protein LSM10provided by MGI
Primary source
MGI:MGI:2151045
See related
Ensembl:ENSMUSG00000050188 AllianceGenome:MGI:2151045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables histone pre-mRNA DCP binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in Cajal body. Predicted to be part of U7 snRNP and cytoplasmic U snRNP body. Predicted to be active in nuclear body. Orthologous to human LSM10 (LSM10, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 18.4), mammary gland adult (RPKM 16.0) and 28 other tissues See more
Orthologs
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Genomic context

See Lsm10 in Genome Data Viewer
Location:
4 D2.2; 4 59.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125990350..125992375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126096562..126098584)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2121 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene STARR-positive B cell enhancer ABC_E3512 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2712 Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene serine/threonine kinase 40 Neighboring gene eva-1 homolog B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables U7 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables U7 snRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables U7 snRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone pre-mRNA DCP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone pre-mRNA DCP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in Cajal body ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of U7 snRNP ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of U7 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of cytoplasmic U snRNP body IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
U7 snRNA-associated Sm-like protein LSm10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163266.2NP_001156738.1  U7 snRNA-associated Sm-like protein LSm10

    See identical proteins and their annotated locations for NP_001156738.1

    Status: VALIDATED

    Source sequence(s)
    AL627101
    Consensus CDS
    CCDS18642.1
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7
    Related
    ENSMUSP00000136585.2, ENSMUST00000179323.2
    Conserved Domains (1) summary
    cd01733
    Location:885
    LSm10; Like-Sm protein 10
  2. NM_001426132.1NP_001413061.1  U7 snRNA-associated Sm-like protein LSm10

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7
  3. NM_001426133.1NP_001413062.1  U7 snRNA-associated Sm-like protein LSm10

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7
  4. NM_138721.3NP_620046.1  U7 snRNA-associated Sm-like protein LSm10

    See identical proteins and their annotated locations for NP_620046.1

    Status: VALIDATED

    Source sequence(s)
    AL627101
    Consensus CDS
    CCDS18642.1
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7
    Related
    ENSMUSP00000061913.8, ENSMUST00000055575.8
    Conserved Domains (1) summary
    cd01733
    Location:885
    LSm10; Like-Sm protein 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125990350..125992375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)