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PPP1R27 protein phosphatase 1 regulatory subunit 27 [ Homo sapiens (human) ]

Gene ID: 116729, updated on 8-Jul-2021

Summary

Official Symbol
PPP1R27provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 27provided by HGNC
Primary source
HGNC:HGNC:16813
See related
Ensembl:ENSG00000182676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DYSFIP1
Expression
Biased expression in prostate (RPKM 3.7), esophagus (RPKM 0.9) and 3 other tissues See more
Orthologs
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Genomic context

See PPP1R27 in Genome Data Viewer
Location:
17q25.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81833492..81835050, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79791368..79792926, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4607 Neighboring gene MAPK regulated corepressor interacting protein 1 Neighboring gene prolyl 4-hydroxylase subunit beta Neighboring gene Rho GDP dissociation inhibitor alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138299

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 27
Names
dysferlin interacting protein 1
dysferlin-interacting protein 1 (toonin)
toonin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007533.4NP_001007534.1  protein phosphatase 1 regulatory subunit 27

    See identical proteins and their annotated locations for NP_001007534.1

    Status: VALIDATED

    Source sequence(s)
    AA722724, BC112094, BI826571, DA894509
    Consensus CDS
    CCDS32767.1
    UniProtKB/Swiss-Prot
    Q86WC6
    Related
    ENSP00000331065.4, ENST00000330261.5
    Conserved Domains (2) summary
    cd00204
    Location:38147
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:6394
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81833492..81835050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160021.1 Reference GRCh38.p13 PATCHES

    Range
    46985..48543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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