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Gp1bb glycoprotein Ib platelet subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 116727, updated on 9-Dec-2024

Summary

Official Symbol
Gp1bbprovided by RGD
Official Full Name
glycoprotein Ib platelet subunit betaprovided by RGD
Primary source
RGD:621050
See related
AllianceGenome:RGD:621050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including blood coagulation, intrinsic pathway; megakaryocyte development; and positive regulation of platelet activation. Predicted to be part of glycoprotein Ib-IX-V complex. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP1BB (glycoprotein Ib platelet subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Spleen (RPKM 69.0), Brain (RPKM 61.9) and 6 other tissues See more
Orthologs
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Genomic context

See Gp1bb in Genome Data Viewer
Location:
11q23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95882561..95883738)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82378216..82379393)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86520992..86522169)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480932 Neighboring gene uncharacterized LOC120095702 Neighboring gene uncharacterized LOC134481101 Neighboring gene septin 5 Neighboring gene T-box transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation, intrinsic pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in megakaryocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of glycoprotein Ib-IX-V complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet glycoprotein Ib beta chain
Names
GP-Ib beta
GPIb-beta
GPIbB
glycoprotein Ib (platelet), beta polypeptide
glycoprotein Ib platelet beta subunit
glycoprotein Ib, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053930.4NP_446382.1  platelet glycoprotein Ib beta chain precursor

    See identical proteins and their annotated locations for NP_446382.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q9JJM7
    Conserved Domains (3) summary
    smart00013
    Location:2559
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:89135
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:5880
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    95882561..95883738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)