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Abcc5 ATP binding cassette subfamily C member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116721, updated on 21-Jul-2018

Summary

Official Symbol
Abcc5provided by RGD
Official Full Name
ATP binding cassette subfamily C member 5provided by RGD
Primary source
RGD:70913
See related
Ensembl:ENSRNOG00000029178
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrp5; Abcc5a
Summary
ATP-binding cassette (ABC) multiple drug resistance protein that mediates efflux cGMP during nitric oxide-induced regulation of smooth muscle [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 1797.5), Brain (RPKM 177.4) and 5 other tissues See more
Orthologs

Genomic context

See Abcc5 in Genome Data Viewer
Location:
11q23
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84395982..84490215)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (87460314..87554521)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene MAP6 domain containing 1 Neighboring gene YEATS domain containing 2 Neighboring gene A-kinase anchor protein 5-like Neighboring gene cytochrome P450, family 2, subfamily ab, polypeptide 1 Neighboring gene presenilin associated, rhomboid-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC156604

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
organic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
organic anion transport IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
multidrug resistance-associated protein 5
Names
ATP-binding cassette sub-family C (CFTR/MRP) member 5a
ATP-binding cassette sub-family C member 5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5a
ATP-binding cassette, subfamily C (CFTR/MRP), member 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053924.1NP_446376.1  multidrug resistance-associated protein 5

    See identical proteins and their annotated locations for NP_446376.1

    Status: PROVISIONAL

    Source sequence(s)
    AB020209
    UniProtKB/Swiss-Prot
    Q9QYM0
    Related
    ENSRNOP00000002316.6, ENSRNOT00000002316.7
    Conserved Domains (4) summary
    cd03244
    Location:11901410
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:577759
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:1001429
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8621142
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    84395982..84490215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248593.2XP_006248655.1  multidrug resistance-associated protein 5 isoform X5

    Conserved Domains (4) summary
    cd03244
    Location:11911411
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:578760
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:1011430
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:8631143
    ABC_membrane; ABC transporter transmembrane region
  2. XM_017597846.1XP_017453335.1  multidrug resistance-associated protein 5 isoform X2

  3. XM_017597845.1XP_017453334.1  multidrug resistance-associated protein 5 isoform X1

  4. XM_017597847.1XP_017453336.1  multidrug resistance-associated protein 5 isoform X3

  5. XM_017597848.1XP_017453337.1  multidrug resistance-associated protein 5 isoform X4

  6. XM_017597849.1XP_017453338.1  multidrug resistance-associated protein 5 isoform X4

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    79313876..79407221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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