aldh1a2 aldehyde dehydrogenase 1 family, member A2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aldh1a2provided by ZNC
Official Full Name: aldehyde dehydrogenase 1 family, member A2provided by ZNC
Primary source: ZFIN:ZDB-GENE-011010-3
See related: Ensembl:ENSDARG00000053493 AllianceGenome:ZFIN:ZDB-GENE-011010-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: raldh2; fb50h01
Summary: Predicted to enable aldehyde dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including chordate embryonic development; myelination; and tube morphogenesis. Is expressed in several structures, including head; heart; immature eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	7	NC_133182.1 (30302598..30344717, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (30327056..30367514, complement)

Chromosome 7 - NC_133182.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of Raldh2 directly.
Title: Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly.
The novel aldh1a2 reporter line is driven by the complete set of regulatory sequences required for zebrafish development, reports novel sources of RA synthesis, and identifies the source of RA that promotes vertebral ossification.
Title: New sources of retinoic acid synthesis revealed by live imaging of an Aldh1a2-GFP reporter fusion protein throughout zebrafish development.
aldh1a2 participate to a positive loop required for branchial arches development in zebrafish
Title: prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish.
Aldh1a2 is the primary aldehyde dehydrogenase acting during pancreas development and maternal Aldh1a2 activity persists in aldh1a2(um22) and aldh1a2(i26) mutant embryos.
Title: Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish.
Studies indicate that raldh2 expression is critical for the formation of wound epithelium and blastema.
Title: Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration.
Present in the mesoderm around the developing inner ear.
Title: Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aldehyde metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axial mesoderm development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination in peripheral nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas field specification	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within paraxial mesoderm development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric duct morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephric duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: retinal dehydrogenase 2

Names: neckless; nls; no-fin; nof; retinaldehyde dehydrogenase 2

NP_571925.1

EC 1.2.1.36

XP_073762183.1

EC 1.2.1.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131850.1 → NP_571925.1 retinal dehydrogenase 2

See identical proteins and their annotated locations for NP_571925.1

Status: PROVISIONAL

Source sequence(s)

AF339837

UniProtKB/TrEMBL

Q90XS8

Related

ENSDARP00000070001.4, ENSDART00000075519.6

Conserved Domains (1) summary

cd07141
Location:32 → 512

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like