U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cga glycoprotein hormones, alpha polypeptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 116700, updated on 23-Nov-2023

Summary

Official Symbol
Cgaprovided by RGD
Official Full Name
glycoprotein hormones, alpha polypeptideprovided by RGD
Primary source
RGD:620436
See related
Ensembl:ENSRNOG00000009269 AllianceGenome:RGD:620436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpa1
Summary
Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in several processes, including positive regulation of steroid biosynthetic process; regulation of signaling receptor activity; and thyroid hormone generation. Predicted to act upstream of or within several processes, including gonadotropin secretion; negative regulation of organ growth; and thyroid gland development. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in extracellular space. Orthologous to human CGA (glycoprotein hormones, alpha polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 1.3), Uterus (RPKM 0.4) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cga in Genome Data Viewer
Location:
5q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (49486915..49499192)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (50362491..50393368)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 292 Neighboring gene small ubiquitin-related modifier 2 pseudogene Neighboring gene ribosomal protein L23a, pseudogene 17 Neighboring gene ubiquitin protein ligase E3 component n-recognin 7, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables follicle-stimulating hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables follicle-stimulating hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables follicle-stimulating hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in biological_process ND
No biological Data available
more info
 
acts_upstream_of_or_within cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within developmental growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of organ growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of follicle-stimulating hormone complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of follicle-stimulating hormone complex ISO
Inferred from Sequence Orthology
more info
 
part_of follicle-stimulating hormone complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of pituitary gonadotropin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glycoprotein hormones alpha chain
Names
FSH-alpha
LSH-alpha
TSH-alpha
anterior pituitary glycoprotein hormones common subunit alpha
follicle-stimulating hormone alpha chain
follitropin alpha chain
glycoprotein hormone alpha subunit
glycoprotein hormones, alpha subunit
luteinizing hormone alpha chain
lutropin alpha chain
pituitary hormone alpha subunit
thyroid-stimulating hormone alpha chain
thyrotropin alpha chain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053918.3NP_446370.3  glycoprotein hormones alpha chain precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000161
    UniProtKB/Swiss-Prot
    P11962, P70516
    UniProtKB/TrEMBL
    A0A0F7RQ24, Q6P509
    Related
    ENSRNOP00000012385.3, ENSRNOT00000012385.5

RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    49486915..49499192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109158.1XP_038965086.1  glycoprotein hormones alpha chain isoform X1

    UniProtKB/Swiss-Prot
    P11962, P70516
    UniProtKB/TrEMBL
    A0A0F7RQ24, Q6P509
    Conserved Domains (1) summary
    pfam00236
    Location:33120
    Hormone_6; Glycoprotein hormone