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Cga glycoprotein hormones, alpha polypeptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 116700, updated on 17-Aug-2024

Summary

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Official Symbol
Cgaprovided by RGD
Official Full Name
glycoprotein hormones, alpha polypeptideprovided by RGD
Primary source
RGD:620436
See related
AllianceGenome:RGD:620436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpa1
Summary
Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in several processes, including positive regulation of steroid biosynthetic process; regulation of signaling receptor activity; and thyroid hormone generation. Predicted to act upstream of or within several processes, including gonadotropin secretion; negative regulation of organ growth; and thyroid gland development. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in extracellular space. Orthologous to human CGA (glycoprotein hormones, alpha polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 1.3), Uterus (RPKM 0.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (54283109..54295464)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (49486915..49499192)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (50362491..50393368)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486924 Neighboring gene small ubiquitin-related modifier 2 pseudogene Neighboring gene ribosomal protein L23a, pseudogene 17 Neighboring gene ubiquitin protein ligase E3 component n-recognin 7, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CGA gene (coding for the alpha subunit of glycoprotein hormones) overexpression in ER alpha-positive prostate tumors. Bièche I, et al. Eur Urol, 2002 Mar. PMID 12180238
  2. The CGA gene as new predictor of the response to endocrine therapy in ER alpha-positive postmenopausal breast cancer patients. Bièche I, et al. Oncogene, 2001 Oct 18. PMID 11687975
  3. Distribution and characterization of alpha hCG in the serum and tumor cytosol of patients with breast cancer. Shindelman JE, et al. Int J Cancer, 1980 May 15. PMID 6768680
  4. Human chorionic gonadotropin and free subunits' serum levels in patients with partial and complete hydatidiform moles. Berkowitz R, et al. Obstet Gynecol, 1989 Aug. PMID 2473429
  5. Isolation and characterization of the gene encoding the alpha-subunit of the rat pituitary glycoprotein hormones. Burnside J, et al. Gene, 1988 Oct 15. PMID 2467841

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that FSH (Cga/FSHb) induces clock system in granulosa cells by up-regulation of connexin 43 expression; this suggests that gap junctions are implicated in circadian clock in peripheral oscillators besides central pacemaker.
    Title: FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway.
  2. Complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes.
    Title: Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression.
  3. histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter
    Title: Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables follicle-stimulating hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables follicle-stimulating hormone activity ISO
Inferred from Sequence Orthology
more info
  
enables follicle-stimulating hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hormone activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within developmental growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of organ growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of steroid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within thyroid gland development ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of follicle-stimulating hormone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of follicle-stimulating hormone complex ISO
Inferred from Sequence Orthology
more info
  
part_of follicle-stimulating hormone complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of pituitary gonadotropin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycoprotein hormones alpha chain
Names
FSH-alpha
LSH-alpha
TSH-alpha
anterior pituitary glycoprotein hormones common subunit alpha
follicle-stimulating hormone alpha chain
follitropin alpha chain
glycoprotein hormone alpha subunit
glycoprotein hormones, alpha subunit
luteinizing hormone alpha chain
lutropin alpha chain
pituitary hormone alpha subunit
thyroid-stimulating hormone alpha chain
thyrotropin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053918.3 → NP_446370.3  glycoprotein hormones alpha chain precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P11962, P70516
    UniProtKB/TrEMBL
    A0A0F7RQ24, Q6P509

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    54283109..54295464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287073.1 → XP_063143143.1  glycoprotein hormones alpha chain isoform X1

    UniProtKB/Swiss-Prot
    P11962, P70516
    UniProtKB/TrEMBL
    A0A0F7RQ24, Q6P509

  2. XM_063287072.1 → XP_063143142.1  glycoprotein hormones alpha chain isoform X1

    UniProtKB/Swiss-Prot
    P11962, P70516
    UniProtKB/TrEMBL
    A0A0F7RQ24, Q6P509
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11962.1 GenPept UniProtKB/Swiss-Prot:P11962

Gene LinkOut

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