U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 [ Mus musculus (house mouse) ]

Gene ID: 11670, updated on 1-Mar-2024

Summary

Official Symbol
Aldh3a1provided by MGI
Official Full Name
aldehyde dehydrogenase family 3, subfamily A1provided by MGI
Primary source
MGI:MGI:1353451
See related
Ensembl:ENSMUSG00000019102 AllianceGenome:MGI:1353451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ahd4; Aldh; Ahd-4; Aldh3
Summary
Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm. Is integral component of membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 55.3), stomach adult (RPKM 53.6) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Aldh3a1 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61099336..61109244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61208510..61218418)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42080 Neighboring gene ribosomal protein S13, pseudogene 5 Neighboring gene aldehyde dehydrogenase family 3, subfamily A2 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular aldehyde metabolic process IC
Inferred by Curator
more info
PubMed 
involved_in cellular aldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aldehyde dehydrogenase, dimeric NADP-preferring
Names
alcohol dehydrogenase family 3, subfamily A1
aldehyde dehydrogenase 3, stomach cytosolic (class 3)
aldehyde dehydrogenase 4
aldehyde dehydrogenase family 3 member A1
dioxin-inducible aldehyde dehydrogenase 3
NP_001106196.1
NP_001318041.1
NP_031462.2
XP_006532086.1
XP_006532087.1
XP_006532089.1
XP_006532090.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112725.1NP_001106196.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

    See identical proteins and their annotated locations for NP_001106196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).
    Source sequence(s)
    AK144241, EL957097, EL959139, EL959277, EL961165, EL963960
    Consensus CDS
    CCDS24808.1
    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Related
    ENSMUSP00000104356.2, ENSMUST00000108716.8
    Conserved Domains (1) summary
    cd07132
    Location:5447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
  2. NM_001331112.1NP_001318041.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).
    Source sequence(s)
    AL646093, CX734286
    UniProtKB/TrEMBL
    B7ZN13
    Conserved Domains (1) summary
    cd07132
    Location:5447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
  3. NM_007436.2NP_031462.2  aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

    See identical proteins and their annotated locations for NP_031462.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).
    Source sequence(s)
    AK144241, AL646093, EL957097, EL959139, EL959277, EL961165, EL963960
    Consensus CDS
    CCDS24808.1
    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Related
    ENSMUSP00000019246.4, ENSMUST00000019246.4
    Conserved Domains (1) summary
    cd07132
    Location:5447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61099336..61109244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532024.3XP_006532087.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

    See identical proteins and their annotated locations for XP_006532087.1

    UniProtKB/TrEMBL
    B7ZN13
    Conserved Domains (1) summary
    cd07132
    Location:5447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
  2. XM_006532027.4XP_006532090.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

    See identical proteins and their annotated locations for XP_006532090.1

    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Conserved Domains (1) summary
    cd07132
    Location:5447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
  3. XM_006532023.1XP_006532086.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

    See identical proteins and their annotated locations for XP_006532086.1

    UniProtKB/TrEMBL
    B7ZN13
    Conserved Domains (1) summary
    cd07132
    Location:5447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
  4. XM_006532026.1XP_006532089.1  aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

    See identical proteins and their annotated locations for XP_006532089.1

    UniProtKB/Swiss-Prot
    B1ATI7, P47739, Q9R203
    UniProtKB/TrEMBL
    Q3UNF5
    Conserved Domains (1) summary
    cd07132
    Location:5447
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins