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Aldh2 aldehyde dehydrogenase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 11669, updated on 2-Apr-2019

Summary

Official Symbol
Aldh2provided by MGI
Official Full Name
aldehyde dehydrogenase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:99600
See related
Ensembl:ENSMUSG00000029455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ahd5; ALDHI; Ahd-5; AHD-M1; ALDH-E2
Expression
Broad expression in adrenal adult (RPKM 574.9), liver adult (RPKM 432.0) and 18 other tissues See more
Orthologs

Genomic context

See Aldh2 in Genome Data Viewer
Location:
5; 5 F
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (121566027..121593824, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122017696..122043833, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NADH binding ISO
Inferred from Sequence Orthology
more info
 
aldehyde dehydrogenase (NAD) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aldehyde dehydrogenase (NAD) activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aldehyde dehydrogenase, mitochondrial
Names
ALDH class 2
NP_001295379.1
NP_033786.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308450.1NP_001295379.1  aldehyde dehydrogenase, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate 3' exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK043506, AK165032, CO039039
    Consensus CDS
    CCDS84951.1
    UniProtKB/TrEMBL
    A0A0G2JEU1, Q544B1
    Related
    ENSMUSP00000142906.1, ENSMUST00000129753.7
    Conserved Domains (1) summary
    cd07141
    Location:33471
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
  2. NM_009656.4NP_033786.1  aldehyde dehydrogenase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_033786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK163452, AK165032, AW050084
    Consensus CDS
    CCDS19638.1
    UniProtKB/Swiss-Prot
    P47738
    UniProtKB/TrEMBL
    Q544B1
    Related
    ENSMUSP00000031411.8, ENSMUST00000031411.14
    Conserved Domains (2) summary
    cd07141
    Location:33513
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    PLN02466
    Location:3518
    PLN02466; aldehyde dehydrogenase family 2 member

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    121566027..121593824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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