Format

Send to:

Choose Destination

F2rl1 F2R like trypsin receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116677, updated on 19-Apr-2019

Summary

Official Symbol
F2rl1provided by RGD
Official Full Name
F2R like trypsin receptor 1provided by RGD
Primary source
RGD:620866
See related
Ensembl:ENSRNOG00000018003
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Par2; Par-2
Summary
G-coupled protein receptor that is activated by coagulation factor II and other serine proteases; may play a role in regulation of exocrine secretion [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 28.2), Heart (RPKM 22.9) and 8 other tissues See more
Orthologs

Genomic context

See F2rl1 in Genome Data Viewer
Location:
2q12
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (25222324..25235275, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (44378262..44391213, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone binding protein Neighboring gene S100 calcium binding protein Z Neighboring gene uncharacterized LOC102550768 Neighboring gene uncharacterized LOC108349923

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
G-protein beta-subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
G-protein beta-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thrombin-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
T cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
PubMed 
T cell activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
PubMed 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction maintenance IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction maintenance ISO
Inferred from Sequence Orthology
more info
PubMed 
chemokine (C-C motif) ligand 2 secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
chemokine (C-C motif) ligand 2 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
chemokine secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
chemokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
interferon-gamma secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-1 beta secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-10 secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
interleukin-10 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration ISO
Inferred from Sequence Orthology
more info
PubMed 
leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
leukocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
mature conventional dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
mature conventional dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of chemokine secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chemokine secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of toll-like receptor 3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
neutrophil activation ISO
Inferred from Sequence Orthology
more info
PubMed 
neutrophil activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of blood vessel diameter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel diameter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine secretion involved in immune response ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytokine secretion involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of eosinophil degranulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of eosinophil degranulation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of glomerular filtration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of interleukin-6 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of interleukin-8 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neutrophil mediated killing of gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neutrophil mediated killing of gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of pseudopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of renin secretion into blood stream ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of renin secretion into blood stream ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of toll-like receptor 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of toll-like receptor 3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
PubMed 
protein secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
PubMed 
thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
pseudopodium ISO
Inferred from Sequence Orthology
more info
PubMed 
pseudopodium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteinase-activated receptor 2
Names
Proteinase-activated receptor-2, G protein-coupled receptor 11
coagulation factor II (thrombin) receptor-like 1
coagulation factor II receptor-like 1
thrombin receptor-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053897.2NP_446349.1  proteinase-activated receptor 2 precursor

    See identical proteins and their annotated locations for NP_446349.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099765
    UniProtKB/Swiss-Prot
    Q63645
    Related
    ENSRNOP00000058298.1, ENSRNOT00000061580.1
    Conserved Domains (2) summary
    pfam00001
    Location:93344
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:154361
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    25222324..25235275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    22836384..22849335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center