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Vwf von Willebrand factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 116669, updated on 7-Sep-2023

Summary

Official Symbol
Vwfprovided by RGD
Official Full Name
von Willebrand factorprovided by RGD
Primary source
RGD:621759
See related
Ensembl:ENSRNOG00000019689 AllianceGenome:RGD:621759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including liver regeneration; platelet activation; and response to L-ascorbic acid. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 693.9), Heart (RPKM 222.5) and 4 other tissues See more
Orthologs
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Genomic context

See Vwf in Genome Data Viewer
Location:
4q42
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (158360152..158491539)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (158085059..158219525)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 212 Neighboring gene CD9 molecule Neighboring gene anoctamin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene neurotrophin 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables collagen binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin binding IEA
Inferred from Electronic Annotation
more info
 
enables immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of blood coagulation via clotting cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within hemostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in hemostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within platelet activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in Weibel-Palade body IEA
Inferred from Electronic Annotation
more info
 
located_in Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053889.1NP_446341.1  von Willebrand factor precursor

    See identical proteins and their annotated locations for NP_446341.1

    Status: VALIDATED

    Source sequence(s)
    BK007994
    UniProtKB/TrEMBL
    A0A8J8XVZ5, A6ILU6, F1M957
    Related
    ENSRNOP00000026643.8, ENSRNOT00000026643.8
    Conserved Domains (11) summary
    smart00041
    Location:27262807
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:24312494
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:377540
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:12771449
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:10531127
    C8; This domain contains 8 conserved cysteine residues
    pfam00092
    Location:14981658
    VWA; von Willebrand factor type A domain
    pfam00094
    Location:35179
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:652707
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:21362199
    C8; C8 domain
    pfam16164
    Location:11981276
    VWA_N2; VWA N-terminal
    cl17735
    Location:25812643
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    158360152..158491539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)