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Vwf von Willebrand factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 116669, updated on 30-Sep-2021

Summary

Official Symbol
Vwfprovided by RGD
Official Full Name
von Willebrand factorprovided by RGD
Primary source
RGD:621759
See related
EnsemblRapid:ENSRNOG00000019689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
human homolog is a plasma glycoprotein that mediates platelet adhesion to damaged blood vessels and stabilizes blood coagulation factor VIII [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 693.9), Heart (RPKM 222.5) and 4 other tissues See more
Orthologs
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Genomic context

See Vwf in Genome Data Viewer
Location:
4q42
Exon count:
52
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (158360152..158491539)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (158085059..158219525)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene CD9 molecule Neighboring gene anoctamin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene neurotrophin 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin binding IEA
Inferred from Electronic Annotation
more info
 
enables immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within hemostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in hemostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within platelet activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in Weibel-Palade body IEA
Inferred from Electronic Annotation
more info
 
located_in Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053889.1NP_446341.1  von Willebrand factor precursor

    See identical proteins and their annotated locations for NP_446341.1

    Status: VALIDATED

    Source sequence(s)
    BK007994
    UniProtKB/TrEMBL
    F1M957
    Related
    ENSRNOP00000026643.8, ENSRNOT00000026643.8
    Conserved Domains (11) summary
    smart00041
    Location:27262807
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:24312494
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:377540
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:12771449
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:10531127
    C8; This domain contains 8 conserved cysteine residues
    pfam00092
    Location:14981658
    VWA; von Willebrand factor type A domain
    pfam00094
    Location:35179
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:652707
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:21362199
    C8; C8 domain
    pfam16164
    Location:11981276
    VWA_N2; VWA N-terminal
    cl17735
    Location:25812643
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    158360152..158491539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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