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Rere arginine-glutamic acid dipeptide repeats [ Rattus norvegicus (Norway rat) ]

Gene ID: 116665, updated on 5-Sep-2025
Official Symbol
Rereprovided by RGD
Official Full Name
arginine-glutamic acid dipeptide repeatsprovided by RGD
Primary source
RGD:629475
See related
Ensembl:ENSRNOG00000017940 AllianceGenome:RGD:629475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arp
Summary
Predicted to enable transcription coactivator activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin remodeling and nervous system development. Predicted to be located in nuclear body. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Orthologous to human RERE (arginine-glutamic acid dipeptide repeats). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 79.2), Kidney (RPKM 63.0) and 9 other tissues See more
Orthologs
human mouse all
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Try the new Transcript table
See Rere in Genome Data Viewer
Location:
5q36
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166048770..166380559)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (160765855..161097678)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (167330966..167664506)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487041 Neighboring gene uncharacterized LOC134487042 Neighboring gene enolase 1 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene uncharacterized LOC120103044 Neighboring gene microRNA 6332 Neighboring gene uncharacterized LOC134487040 Neighboring gene LYR motif containing 1, pseudogene 1 Neighboring gene solute carrier family 45, member 1 Neighboring gene uncharacterized LOC120103185

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Genotype-phenotype correlations in individuals with pathogenic RERE variants. Jordan VK, et al. Hum Mutat, 2018 May. PMID 29330883, Free PMC Article
  2. cDNA cloning and characterization of an atrophin-1 (DRPLA disease gene)-related protein. Khan FA, et al. Neurobiol Dis, 1996 Apr. PMID 9173919
  3. RERE deficiency contributes to the development of orofacial clefts in humans and mice. Kim BJ, et al. Hum Mol Genet, 2021 May 12. PMID 33772547
  4. RERE deficiency causes retinal and optic nerve atrophy through degeneration of retinal cells. Kim BJ, et al. Dev Dyn, 2021 Oct. PMID 33742727
  5. Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. Kim BJ, et al. PLoS One, 2014. PMID 24466353, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within branching morphogenesis of a nerve IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer maturation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar granule cell precursor proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellum development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellum development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within radial glia guided migration of Purkinje cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within radial glia guided migration of Purkinje cell ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
part_of histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
  
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
arginine-glutamic acid dipeptide repeats protein
Names
arginine-glutamic acid dipeptide (RE) repeats
atrophin-1-related protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053885.2 → NP_446337.2  arginine-glutamic acid dipeptide repeats protein

    See identical proteins and their annotated locations for NP_446337.2

    Status: VALIDATED

    Source sequence(s)
    AI113241, AW920332, CA511326, CB328253, CB728130, CK470955, JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q62901
    UniProtKB/TrEMBL
    A0A8I6A4P7, A6IUD6
    Conserved Domains (7) summary
    smart00717
    Location:395 → 440
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:394 → 439
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:502 → 551
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:505 → 559
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 306
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:285 → 335
    ELM2; ELM2 domain
    pfam03154
    Location:567 → 1558
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    166048770..166380559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764198.4 → XP_008762420.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    See identical proteins and their annotated locations for XP_008762420.1

    UniProtKB/TrEMBL
    A0A8I6A4P7
    Conserved Domains (7) summary
    smart00717
    Location:395 → 440
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:394 → 439
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:502 → 551
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:505 → 559
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 306
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:285 → 335
    ELM2; ELM2 domain
    pfam03154
    Location:567 → 1566
    Atrophin-1; Atrophin-1 family

  2. XM_008764201.4 → XP_008762423.1  arginine-glutamic acid dipeptide repeats protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6A4P7
    Related
    ENSRNOP00000085727.2, ENSRNOT00000095232.2
    Conserved Domains (7) summary
    smart00717
    Location:353 → 398
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:352 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:460 → 509
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:463 → 517
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 264
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:243 → 293
    ELM2; ELM2 domain
    pfam03154
    Location:525 → 1524
    Atrophin-1; Atrophin-1 family

  3. XM_006239438.5 → XP_006239500.1  arginine-glutamic acid dipeptide repeats protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4P7
    Related
    ENSRNOP00000024443.5, ENSRNOT00000024443.5
    Conserved Domains (7) summary
    smart00717
    Location:395 → 440
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:394 → 439
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:502 → 551
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:505 → 559
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 306
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:285 → 335
    ELM2; ELM2 domain
    pfam03154
    Location:567 → 1565
    Atrophin-1; Atrophin-1 family

  4. XM_008764200.4 → XP_008762422.1  arginine-glutamic acid dipeptide repeats protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6A4P7
    Conserved Domains (7) summary
    smart00717
    Location:395 → 440
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:394 → 439
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:502 → 551
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:505 → 559
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 306
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:285 → 335
    ELM2; ELM2 domain
    pfam03154
    Location:567 → 1557
    Atrophin-1; Atrophin-1 family

  5. XM_063287069.1 → XP_063143139.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4P7

  6. XM_063287068.1 → XP_063143138.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4P7

  7. XM_008764199.4 → XP_008762421.1  arginine-glutamic acid dipeptide repeats protein isoform X1

    See identical proteins and their annotated locations for XP_008762421.1

    UniProtKB/TrEMBL
    A0A8I6A4P7
    Conserved Domains (7) summary
    smart00717
    Location:395 → 440
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:394 → 439
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:502 → 551
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:505 → 559
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:101 → 306
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:285 → 335
    ELM2; ELM2 domain
    pfam03154
    Location:567 → 1566
    Atrophin-1; Atrophin-1 family

  8. XM_063287070.1 → XP_063143140.1  arginine-glutamic acid dipeptide repeats protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6A4P7

  9. XM_006239441.5 → XP_006239503.1  arginine-glutamic acid dipeptide repeats protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6A9U2
    Related
    ENSRNOP00000089254.1, ENSRNOT00000103362.2
    Conserved Domains (6) summary
    smart00717
    Location:128 → 173
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:127 → 172
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:235 → 284
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:238 → 292
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam01448
    Location:18 → 68
    ELM2; ELM2 domain
    pfam03154
    Location:300 → 1299
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62901.2 GenPept UniProtKB/Swiss-Prot:Q62901

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