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Cplx2 complexin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116657, updated on 22-Aug-2021

Summary

Official Symbol
Cplx2provided by RGD
Official Full Name
complexin 2provided by RGD
Primary source
RGD:70945
See related
Ensembl:ENSRNOG00000000105
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
binds the assembled SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex; modulates synaptic vesicle exocytosis [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 1041.7) and Adrenal (RPKM 63.0) See more
Orthologs
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Genomic context

See Cplx2 in Genome Data Viewer
Location:
17p14
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (10219577..10292835, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10756871..10828811, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene THO complex 3 Neighboring gene uncharacterized LOC120097924 Neighboring gene long non-coding RNA 012 Neighboring gene histamine receptor H 2 Neighboring gene uncharacterized LOC120097817

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton HDA PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complexin-2
Names
CPX II
complexin II
synaphin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053878.2NP_446330.1  complexin-2

    See identical proteins and their annotated locations for NP_446330.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000284
    UniProtKB/Swiss-Prot
    P84087
    Related
    ENSRNOP00000000117.1, ENSRNOT00000000117.2
    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    10219577..10292835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095303.1XP_038951231.1  complexin-2 isoform X1

    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein
  2. XM_017600441.2XP_017455930.1  complexin-2 isoform X1

    UniProtKB/Swiss-Prot
    P84087
    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein
  3. XM_017600440.2XP_017455929.1  complexin-2 isoform X1

    UniProtKB/Swiss-Prot
    P84087
    Related
    ENSRNOP00000072664.1
    Conserved Domains (1) summary
    pfam05835
    Location:1133
    Synaphin; Synaphin protein
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