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Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116649, updated on 8-Dec-2022

Summary

Official Symbol
Kcnj4provided by RGD
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 4provided by RGD
Primary source
RGD:621436
See related
Ensembl:ENSRNOG00000013869 AllianceGenome:RGD:621436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hirk2
Summary
Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Involved in cellular response to mechanical stimulus. Located in dendrite and neuronal cell body. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 73.5) and Lung (RPKM 12.5) See more
Orthologs
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Genomic context

See Kcnj4 in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111047097..111074151, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120717378..120744602, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene casein kinase 1, epsilon Neighboring gene uncharacterized LOC120093689 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 3 Neighboring gene DEAD-box helicase 17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inward rectifier potassium channel 4
Names
BIR11
IRK-3
IRK3
brain inwardly rectifying K(+) channel 2
inward rectifier K(+) channel Kir2.3
potassium channel, inwardly rectifying subfamily J member 4
potassium voltage-gated channel subfamily J member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053870.3NP_446322.2  inward rectifier potassium channel 4

    See identical proteins and their annotated locations for NP_446322.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000186
    UniProtKB/Swiss-Prot
    P52190
    UniProtKB/TrEMBL
    G3V9M7
    Related
    ENSRNOP00000053014.1, ENSRNOT00000018564.7
    Conserved Domains (1) summary
    pfam01007
    Location:22357
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    111047097..111074151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594575.2XP_017450064.1  inward rectifier potassium channel 4 isoform X1

    UniProtKB/TrEMBL
    G3V9M7
  2. XM_006241964.4XP_006242026.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006242026.1

    UniProtKB/TrEMBL
    G3V9M7
    Conserved Domains (1) summary
    pfam01007
    Location:22357
    IRK; Inward rectifier potassium channel
  3. XM_006241963.4XP_006242025.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006242025.1

    UniProtKB/TrEMBL
    G3V9M7
    Conserved Domains (1) summary
    pfam01007
    Location:22357
    IRK; Inward rectifier potassium channel