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Csf2 colony stimulating factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116630, updated on 6-May-2021

Summary

Official Symbol
Csf2provided by RGD
Official Full Name
colony stimulating factor 2provided by RGD
Primary source
RGD:621065
See related
Ensembl:ENSRNOG00000026805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gmcsf; Gm-csf
Summary
plays a role in alveolar epithelial fluid transport [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 22.7) and Thymus (RPKM 6.6) See more
Orthologs
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Genomic context

See Csf2 in Genome Data Viewer
Location:
10q22
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38386945..38388926, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39602089..39604070, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit alpha 2 Neighboring gene casein kinase 2, alpha 1 polypeptide Neighboring gene interleukin 3 Neighboring gene uncharacterized LOC120095100 Neighboring gene acyl-CoA synthetase long-chain family member 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables granulocyte macrophage colony-stimulating factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in epithelial fluid transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-23 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of trophectodermal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to silicon dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
granulocyte-macrophage colony-stimulating factor
Names
CSF
colony stimulating factor 2 (granulocyte-macrophage)
colony-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053852.1NP_446304.1  granulocyte-macrophage colony-stimulating factor precursor

    See identical proteins and their annotated locations for NP_446304.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000219
    UniProtKB/Swiss-Prot
    P48750
    Related
    ENSRNOP00000034235.3, ENSRNOT00000032333.3
    Conserved Domains (1) summary
    cd00040
    Location:18138
    CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    38386945..38388926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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