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Csf2 colony stimulating factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116630, updated on 22-Nov-2020

Summary

Official Symbol
Csf2provided by RGD
Official Full Name
colony stimulating factor 2provided by RGD
Primary source
RGD:621065
See related
Ensembl:ENSRNOG00000026805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gmcsf; Gm-csf
Summary
plays a role in alveolar epithelial fluid transport [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 22.7) and Thymus (RPKM 6.6) See more
Orthologs

Genomic context

See Csf2 in Genome Data Viewer
Location:
10q22
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39602089..39604070, complement)
106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (37727629..37729611, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (39379120..39381430, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit alpha 2 Neighboring gene casein kinase 2, alpha 1 polypeptide Neighboring gene interleukin 3 Neighboring gene uncharacterized LOC102551269

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
granulocyte macrophage colony-stimulating factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
TOR signaling ISO
Inferred from Sequence Orthology
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
epithelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
epithelial fluid transport IDA
Inferred from Direct Assay
more info
PubMed 
histamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neutrophil differentiation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-23 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of trophectodermal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
response to fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to silicon dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
granulocyte-macrophage colony-stimulating factor
Names
CSF
colony stimulating factor 2 (granulocyte-macrophage)
colony-stimulating factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053852.1NP_446304.1  granulocyte-macrophage colony-stimulating factor precursor

    See identical proteins and their annotated locations for NP_446304.1

    Status: VALIDATED

    Source sequence(s)
    AABR07029603
    UniProtKB/Swiss-Prot
    P48750
    Related
    ENSRNOP00000034235.3, ENSRNOT00000032333.3
    Conserved Domains (1) summary
    cd00040
    Location:18138
    CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    39602089..39604070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    37727629..37729611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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