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Pdia4 protein disulfide isomerase family A, member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116598, updated on 12-Jan-2022

Summary

Official Symbol
Pdia4provided by RGD
Official Full Name
protein disulfide isomerase family A, member 4provided by RGD
Primary source
RGD:619835
See related
Ensembl:ENSRNOG00000006228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Erp70; Erp72; ERp-72
Summary
Enables protein disulfide isomerase activity. Involved in chaperone-mediated protein folding and positive regulation of protein folding. Located in smooth endoplasmic reticulum. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Liver (RPKM 1652.1), Spleen (RPKM 499.5) and 9 other tissues See more
Orthologs
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Genomic context

See Pdia4 in Genome Data Viewer
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (76803198..76822245, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (77470636..77489535, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene cullin 1 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene uncharacterized LOC120102262 Neighboring gene zinc finger protein 786 Neighboring gene zinc finger protein 398

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
part_of endoplasmic reticulum chaperone complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein disulfide-isomerase A4
Names
ER protein 70
ER protein 72
caBP2
calcium-binding protein 2
endoplasmic reticulum resident protein 70
endoplasmic reticulum resident protein 72
protein disulfide isomerase associated 4
protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)
NP_446301.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053849.2NP_446301.2  protein disulfide-isomerase A4 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000142
    Related
    ENSRNOP00000008728.4, ENSRNOT00000008728.6
    Conserved Domains (2) summary
    TIGR01126
    Location:65166
    pdi_dom; protein disulfide-isomerase domain
    TIGR01130
    Location:175635
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    76803198..76822245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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