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Mapk1 mitogen activated protein kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116590, updated on 4-Nov-2018

Summary

Official Symbol
Mapk1provided by RGD
Official Full Name
mitogen activated protein kinase 1provided by RGD
Primary source
RGD:70500
See related
Ensembl:ENSRNOG00000001849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ERT1; Erk2; ERK-2; p42-MAPK
Summary
kinase involved in intracellular signaling; component of Mapk signaling pathway [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 291.5), Adrenal (RPKM 150.7) and 9 other tissues See more
Orthologs

Genomic context

See Mapk1 in Genome Data Viewer
Location:
11q23
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88203863..88273301, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (91260412..91325570, complement)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase like 2 Neighboring gene yippee-like 1 Neighboring gene uncharacterized LOC103690734 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1F Neighboring gene DNA topoisomerase III beta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase activity TAS
Traceable Author Statement
more info
PubMed 
MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity TAS
Traceable Author Statement
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IC
Inferred by Curator
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Bergmann glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
ERBB signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ERBB signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac neural crest cell development involved in heart development IEA
Inferred from Electronic Annotation
more info
 
cardiac neural crest cell development involved in heart development ISO
Inferred from Sequence Orthology
more info
 
caveolin-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to dopamine IEA
Inferred from Electronic Annotation
more info
 
cellular response to dopamine ISO
Inferred from Sequence Orthology
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
cytosine metabolic process IEA
Inferred from Electronic Annotation
more info
 
cytosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
diadenosine tetraphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
face development IEA
Inferred from Electronic Annotation
more info
 
face development ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
neural crest cell development ISO
Inferred from Sequence Orthology
more info
 
outer ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outer ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomerase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere capping IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular pH IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular pH ISO
Inferred from Sequence Orthology
more info
 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
response to epidermal growth factor ISO
Inferred from Sequence Orthology
more info
 
response to epidermal growth factor ISS
Inferred from Sequence or Structural Similarity
more info
 
response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
trachea formation IEA
Inferred from Electronic Annotation
more info
 
trachea formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
caveola TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
early endosome TAS
Traceable Author Statement
more info
PubMed 
focal adhesion TAS
Traceable Author Statement
more info
PubMed 
late endosome TAS
Traceable Author Statement
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
pseudopodium IEA
Inferred from Electronic Annotation
more info
 
pseudopodium ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 1
Names
MAP kinase 1
MAP kinase 2
MAP kinase isoform p42
MAPK 1
MAPK 2
extracellular-signal-regulated kinase 2
mitogen-activated protein kinase 2
NP_446294.1
XP_006248720.1
XP_006248721.1
XP_008767070.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053842.2NP_446294.1  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_446294.1

    Status: VALIDATED

    Source sequence(s)
    AC110316, AC128500
    UniProtKB/Swiss-Prot
    P63086
    Related
    ENSRNOP00000002533.6, ENSRNOT00000002533.7
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    88203863..88273301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768848.2XP_008767070.1  mitogen-activated protein kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_008767070.1

    UniProtKB/Swiss-Prot
    P63086
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  2. XM_006248658.3XP_006248720.1  mitogen-activated protein kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006248720.1

    UniProtKB/Swiss-Prot
    P63086
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  3. XM_006248659.3XP_006248721.1  mitogen-activated protein kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_006248721.1

    UniProtKB/Swiss-Prot
    P63086
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    82713470..82779260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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