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Alcam activated leukocyte cell adhesion molecule [ Mus musculus (house mouse) ]

Gene ID: 11658, updated on 13-Dec-2022

Summary

Official Symbol
Alcamprovided by MGI
Official Full Name
activated leukocyte cell adhesion moleculeprovided by MGI
Primary source
MGI:MGI:1313266
See related
Ensembl:ENSMUSG00000022636 AllianceGenome:MGI:1313266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BEN; SC1; MuSC; CD166; DM-GRASP
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within motor neuron axon guidance. Located in axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and vibrissa. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 24.3), CNS E11.5 (RPKM 16.7) and 24 other tissues See more
Orthologs
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Genomic context

See Alcam in Genome Data Viewer
Location:
16; 16 B5
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (52069359..52273444, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (52248996..52453081, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29686 Neighboring gene Casitas B-lineage lymphoma b Neighboring gene predicted gene, 23513 Neighboring gene predicted gene, 32597 Neighboring gene predicted gene, 41461 Neighboring gene predicted gene, 52279 Neighboring gene RIKEN cDNA 4930404A05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27910

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331110.1NP_001318039.1  CD166 antigen isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC117780, AC154383, BE654940
    Consensus CDS
    CCDS84242.1
    UniProtKB/TrEMBL
    E9Q3Q6
    Related
    ENSMUSP00000129714.2, ENSMUST00000170035.8
  2. NM_009655.3NP_033785.1  CD166 antigen isoform 1 precursor

    See identical proteins and their annotated locations for NP_033785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154383, AK031391, AK161090, BE654940
    Consensus CDS
    CCDS37356.1
    UniProtKB/Swiss-Prot
    Q61490, Q8R2T0
    UniProtKB/TrEMBL
    Q3TTY3, Q54AJ5
    Related
    ENSMUSP00000023312.8, ENSMUST00000023312.14
    Conserved Domains (4) summary
    smart00410
    Location:255329
    IG_like; Immunoglobulin like
    pfam08205
    Location:137231
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:256313
    Ig_3; Immunoglobulin domain
    cl11960
    Location:415488
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    52069359..52273444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)