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Ggt1 gamma-glutamyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116568, updated on 2-Oct-2018

Summary

Official Symbol
Ggt1provided by RGD
Official Full Name
gamma-glutamyltransferase 1provided by RGD
Primary source
RGD:2683
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ggt; Ggtp; GGLUT
Summary
required in the glutathione metabolism [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Restricted expression toward (RPKM 1821.2) See more
Orthologs

Genomic context

See Ggt1 in Genome Data Viewer
Location:
20p12
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (14019723..14045781, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (16209337..16231303, complement)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene sushi domain containing 2 Neighboring gene gamma-glutamyltransferase 5 Neighboring gene leucine rich repeat containing 75B Neighboring gene small nuclear ribonucleoprotein D3 polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the Ggt1 gene: The Ggt1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
  • Orthologs from Annotation Pipeline: 202 organisms have orthologs with human gene Ggt1

Gene Ontology Provided by RGD

Function Evidence Code Pubs
glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
glutathione hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
glutathione hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
hypoglycin A gamma-glutamyl transpeptidase activity IEA
Inferred from Electronic Annotation
more info
 
leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
leukotriene-C(4) hydrolase ISO
Inferred from Sequence Orthology
more info
 
peptidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity, transferring amino-acyl groups IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
cysteine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
glutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glutamate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
glutathione biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione catabolic process ISO
Inferred from Sequence Orthology
more info
 
glutathione catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukotriene D4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
peptide modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide modification IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of immune system process ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
zymogen activation ISO
Inferred from Sequence Orthology
more info
 
zymogen activation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione hydrolase 1 proenzyme
Names
GGT 1
gamma glutamyl-transferase 1
gamma-glutamyl transpeptidase
gamma-glutamyltranspeptidase 1
glutathione hydrolase 1
leukotriene-C4 hydrolase
NP_446292.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053840.2NP_446292.2  glutathione hydrolase 1 proenzyme

    See identical proteins and their annotated locations for NP_446292.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078768
    UniProtKB/Swiss-Prot
    P07314
    Conserved Domains (1) summary
    pfam01019
    Location:55563
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    14019723..14045781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    14560916..14581414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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