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Mapk8 mitogen-activated protein kinase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116554, updated on 8-Dec-2022

Summary

Official Symbol
Mapk8provided by RGD
Official Full Name
mitogen-activated protein kinase 8provided by RGD
Primary source
RGD:621506
See related
Ensembl:ENSRNOG00000020155 AllianceGenome:RGD:621506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
JNK
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]
Expression
Biased expression in Brain (RPKM 159.1), Muscle (RPKM 92.9) and 9 other tissues See more
Orthologs
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Genomic context

See Mapk8 in Genome Data Viewer
Location:
16p16
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (8638897..8721960, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (9620854..9709342, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rho GTPase activating protein 22 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene protein tyrosine phosphatase, non-receptor type 20

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within JUN phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in JUN phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cyclase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription factor catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within programmed necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to tricellular tight junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of dense core granule transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in basal dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in podosome ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 8
Names
MAP kinase 8
MAPK 8
SAPK gamma
c-Jun N-terminal kinase 1
c-jun NH2-terminal kinase
p54 gamma
stress-activated protein kinase JNK1
NP_446281.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053829.2NP_446281.2  mitogen-activated protein kinase 8

    Status: REVIEWED

    Source sequence(s)
    AA963835, CB782828, DV724511, FM076271, JACYVU010000273, L27129
    UniProtKB/Swiss-Prot
    P49185
    Related
    ENSRNOP00000082511.1, ENSRNOT00000099742.1
    Conserved Domains (2) summary
    smart00220
    Location:26321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    8638897..8721960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)