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MRGPRF MAS related GPR family member F [ Homo sapiens (human) ]

Gene ID: 116535, updated on 22-Sep-2022

Summary

Official Symbol
MRGPRFprovided by HGNC
Official Full Name
MAS related GPR family member Fprovided by HGNC
Primary source
HGNC:HGNC:24828
See related
Ensembl:ENSG00000172935 MIM:607233; AllianceGenome:HGNC:24828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RTA; MRGF; GPR140; GPR168
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in nuclear membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in endometrium (RPKM 20.4), prostate (RPKM 13.8) and 18 other tissues See more
Orthologs
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Genomic context

See MRGPRF in Genome Data Viewer
Location:
11q13.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69004398..69013633, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69014626..69023473, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68771866..68780714, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene MAS related GPR family member D Neighboring gene MRGPRF antisense RNA 1 Neighboring gene uncharacterized LOC124902701 Neighboring gene uncharacterized LOC124902702 Neighboring gene two pore segment channel 2 Neighboring gene microRNA 3164

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16111, FLJ29034, FLJ40998, FLJ53714, MGC21621, DKFZp586B2122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mas-related G-protein coupled receptor member F
Names
G protein-coupled receptor MrgF
G-protein coupled receptor 140
G-protein coupled receptor 168
MAS-related GPR, member F
Mas-related G protein-coupled receptor F
mas-related G protein-coupled MRGF
mas-related gene F protein
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098515.2NP_001091985.1  mas-related G-protein coupled receptor member F

    See identical proteins and their annotated locations for NP_001091985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK122669, BC016964
    Consensus CDS
    CCDS8188.1
    UniProtKB/Swiss-Prot
    Q8NBK8, Q96AM1
    UniProtKB/TrEMBL
    A0A024R5F0
    Related
    ENSP00000403660.1, ENST00000441623.1
    Conserved Domains (1) summary
    cd15109
    Location:45318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_145015.5NP_659452.3  mas-related G-protein coupled receptor member F

    See identical proteins and their annotated locations for NP_659452.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC016964, BP376260
    Consensus CDS
    CCDS8188.1
    UniProtKB/Swiss-Prot
    Q8NBK8, Q96AM1
    UniProtKB/TrEMBL
    A0A024R5F0
    Related
    ENSP00000309782.6, ENST00000309099.7
    Conserved Domains (1) summary
    cd15109
    Location:45318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    69004398..69013633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448339.2XP_024304107.1  mas-related G-protein coupled receptor member F isoform X1

    UniProtKB/Swiss-Prot
    Q8NBK8
    UniProtKB/TrEMBL
    A0A024R5F0
    Conserved Domains (1) summary
    cd15109
    Location:45318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017017170.2XP_016872659.1  mas-related G-protein coupled receptor member F isoform X1

    UniProtKB/Swiss-Prot
    Q8NBK8, Q96AM1
    UniProtKB/TrEMBL
    A0A024R5F0
    Conserved Domains (1) summary
    cd15109
    Location:45318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    69014626..69023473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)