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Calcr calcitonin receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 116506, updated on 5-Sep-2025
Official Symbol
Calcrprovided by RGD
Official Full Name
calcitonin receptorprovided by RGD
Primary source
RGD:621001
See related
Ensembl:ENSRNOG00000010053 AllianceGenome:RGD:621001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcitonin binding activity and calcitonin receptor activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cellular response to transforming growth factor beta stimulus; and cellular response to tumor necrosis factor. Located in axon and neuronal cell body. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (calcitonin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 27.7), Brain (RPKM 15.8) and 1 other tissue See more
Orthologs
human mouse all
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See Calcr in Genome Data Viewer
Location:
4q13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (32615955..32691075, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (31661270..31736392, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (28627439..28702559, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene HEPACAM family member 2 Neighboring gene VPS50 subunit of EARP/GARPII complex Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene tissue factor pathway inhibitor 2 Neighboring gene G protein subunit gamma transducin 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Decline in calcitonin receptor expression in osteocytes with age. Gooi JH, et al. J Endocrinol, 2014 May. PMID 24516262
  2. Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat. Tolcos M, et al. J Comp Neurol, 2003 Jan 27. PMID 12508311
  3. Calcitonin receptor isoforms expressed in the developing rat kidney. Tikellis C, et al. Kidney Int, 2003 Feb. PMID 12631107
  4. Identification of brain isoforms of the rat calcitonin receptor. Sexton PM, et al. Mol Endocrinol, 1993 Jun. PMID 8395656
  5. Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin. Albrandt K, et al. FEBS Lett, 1993 Jul 5. PMID 8391477

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In conclusion, oral KBP-042 is a novel DACRA, which exerts antiobesity and antidiabetic efficacy by dual modulation of insulin sensitivity and directly decelerating stress on the pancreatic alpha- and beta-cells.
    Title: A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats.
  2. Calcitonin receptor mRNA expression declines with age on osteocytes.
    Title: Decline in calcitonin receptor expression in osteocytes with age.
  3. variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent Herpes simplex encephalitis development.
    Title: The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.
  4. RAMP interaction with the CTRa in COS-7 or HEK-293 cells leads to selective modulation of signaling pathways activated by the receptor complex.
    Title: Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors.
  5. calcitonin receptor C1a protein expression has been identified in the ureteric ducts in the metanephros and both isoforms expressed in the distal portions of the developing nephrons and collecting ducts
    Title: Calcitonin receptor isoforms expressed in the developing rat kidney.
  6. Abundant expression of calcitonin C1 receptors was found in the nucleus accumbens, lateral arcuate nucleus, lateral substantia nigra, bed nucleus, locus coeruleus, area postrema, nucleus of the solitary tract, and some nuclei of the reticular formation.
    Title: Immunohistochemical mapping of calcitonin receptors in the adult rat brain.
  7. By using in situ hybridization, the codistribution of CT((a))/CT((b)) with RAMP1-3 and c-fos was mapped in CVOs of rats.
    Title: Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat.
  8. These studies indicate a role for CTR in the activation of some premigratory neuroblasts in the CNS.
    Title: Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables amylin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables calcitonin binding ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin binding ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin family receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin gene-related peptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcitonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcitonin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in amylin receptor 1 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in amylin receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in amylin receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in amylin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in calcitonin family receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in calcitonin gene-related peptide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mononuclear cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cAMP/PKA signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of amylin receptor complex 1 ISO
Inferred from Sequence Orthology
more info
  
part_of amylin receptor complex 2 ISO
Inferred from Sequence Orthology
more info
  
part_of amylin receptor complex 3 ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
calcitonin receptor
Names
C1A/C1B
CT-R

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034015.1 → NP_001029187.1  calcitonin receptor isoform 1a precursor

    See identical proteins and their annotated locations for NP_001029187.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1a, previously called 2), lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a, previously called b), has the same N- and C-termini but is shorter compared to isoform 1b.
    Source sequence(s)
    CB791100, L14617
    UniProtKB/TrEMBL
    A0A0H2UHI3, A6K2A3, A6K2A6
    Related
    ENSRNOP00000013937.6, ENSRNOT00000013937.7
    Conserved Domains (2) summary
    pfam00002
    Location:162 → 404
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:86 → 154
    HRM; Hormone receptor domain

  2. NM_053816.2 → NP_446268.2  calcitonin receptor isoform 1b precursor

    See identical proteins and their annotated locations for NP_446268.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1b), previously called 1, represents the longer variant and encodes the longer isoform (1b, previously called a).
    Source sequence(s)
    CB791100, L14617, L14618
    UniProtKB/Swiss-Prot
    P32213, P32214
    UniProtKB/TrEMBL
    A0A0H2UHI1, A6K2A4, A6K2A7
    Related
    ENSRNOP00000013910.6, ENSRNOT00000013910.9
    Conserved Domains (2) summary
    pfam00002
    Location:162 → 441
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:86 → 154
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    32615955..32691075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32214.1 GenPept UniProtKB/Swiss-Prot:P32214

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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