Stx1a syntaxin 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stx1aprovided by RGD
Official Full Name: syntaxin 1Aprovided by RGD
Primary source: RGD:69430
See related: Ensembl:ENSRNOG00000029165 AllianceGenome:RGD:69430
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle docking. Located in actomyosin; plasma membrane; and secretory granule. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; synaptic membrane; and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 252.7) and Thymus (RPKM 12.6) See more
Orthologs: all
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Genomic context

Location:: 12q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (27278517..27306547, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21641971..21670022, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (24682050..24710002, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A.
Title: SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A.
Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model.
Title: Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model.
Changes in concentrations of NMDA receptor subunit GluN2B, Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a rat learned helplessness model of depression.
Title: Changes in concentrations of NMDA receptor subunit GluN2B, Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a rat learned helplessness model of depression.
CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells.
Title: CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells.
Munc18-dependent and -independent clustering of syntaxin in the plasma membrane of cultured endocrine cells.
Title: Munc18-dependent and -independent clustering of syntaxin in the plasma membrane of cultured endocrine cells.
The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE-SNARE interactions.
Title: The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE-SNARE interactions.
Syntaxin 1A Gene Is Negatively Regulated in a Cell/Tissue Specific Manner by YY1 Transcription Factor, Which Binds to the -183 to -137 Promoter Region Together with Gene Silencing Factors Including Histone Deacetylase.
Title: Syntaxin 1A Gene Is Negatively Regulated in a Cell/Tissue Specific Manner by YY1 Transcription Factor, Which Binds to the -183 to -137 Promoter Region Together with Gene Silencing Factors Including Histone Deacetylase.
Re-examining how Munc13-1 facilitates opening of syntaxin-1.
Title: Re-examining how Munc13-1 facilitates opening of syntaxin-1.
Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.
Title: Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.
Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.
Title: Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048378 (e-PCR)
- UniSTS:109594

Stx1a (e-PCR), detects polymorphism
- UniSTS:230798

BF397463 (e-PCR)
- UniSTS:246174

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables SNARE binding	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium channel inhibitor activity	IEA Inferred from Electronic Annotation more info
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables chloride channel inhibitor activity	IEA Inferred from Electronic Annotation more info
enables chloride channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin head/neck binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SNARE complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SNARE complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium-ion regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in modulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of calcium ion-dependent exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of catecholamine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of norepinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of secretion by cell	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle priming	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in response to gravity	IDA Inferred from Direct Assay more info	PubMed
involved_in secretion by cell	IEA Inferred from Electronic Annotation more info
involved_in secretion by cell	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle docking	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in actomyosin	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA Inferred from Direct Assay more info	PubMed
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IEA Inferred from Electronic Annotation more info
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex	ISO Inferred from Sequence Orthology more info
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IDA Inferred from Direct Assay more info	PubMed
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: syntaxin-1A

Names: P35A; neuron-specific antigen HPC-1; synaptotagmin-associated 35 kDa protein; syntaxin 1A (brain); syntaxin 1A (brain)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.