Akr1b7 aldo-keto reductase family 1, member B7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Akr1b7provided by RGD
Full Name: aldo-keto reductase family 1, member B7provided by RGD
Primary source: RGD:620257
See related: Ensembl:ENSRNOG00000009875 AllianceGenome:RGD:620257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Avdp; MVDP; Akr1b14
Summary: Predicted to enable aldose reductase (NADPH) activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be active in cytosol and mitochondrion. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Restricted expression toward (RPKM 7763.2) See more
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Genomic context

Location:: 4q22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (64043901..64083751)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (63053560..63100934)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (61850256..61879733)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The bile acid binding to AKR1B14 mainly accelerates the NADP(+) dissociation, the rate-limited step of the enzyme reaction
Title: Activation of aldo-keto reductase family member 1B14 (AKR1B14) by bile acids: Activation mechanism and bile acid-binding site.
crystal structure of the AKR1B14 His269Arg mutant in complex with NADPH was refined at 1.87 A degrees resolution
Title: Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH.
AKR1B14 was crystallized from polyethylene glycol solutions using the hanging-drop vapour-diffusion method and an X-ray diffraction data set was collected to 1.86 A resolution.
Title: Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14).
Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions
Title: Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions.
expression of akr1b7 mRNA in rat liver is sexually differentiated, expressed in females but not in males, and regulated by the sexually dimorphic secretion pattern of GH.
Title: Activation of the glucocorticoid receptor or liver X receptors interferes with growth hormone-induced akr1b7 gene expression in rat hepatocytes.
expression in rat vas deferens is barely detectable and is not androgen sensitive
Title: A 77-base pair LINE-like sequence elicits androgen-dependent mvdp/akr1-b7 expression in mouse vas deferens, but is dispensable for adrenal expression in rats.

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General gene information

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Markers

BF390404 (e-PCR)
- UniSTS:249459

RH140894 (e-PCR)
- UniSTS:222910

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin H2 endoperoxidase reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member B7

Names: aldehyde reductase; aldose reductase-like protein AKR1B14; aldose reductase-related protein 1; androgen regulated vas deferens protein

NP_446233.2

EC 1.1.1.21

XP_063141472.1

EC 1.1.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.