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TM4SF18 transmembrane 4 L six family member 18 [ Homo sapiens (human) ]

Gene ID: 116441, updated on 23-Nov-2021

Summary

Official Symbol
TM4SF18provided by HGNC
Official Full Name
transmembrane 4 L six family member 18provided by HGNC
Primary source
HGNC:HGNC:25181
See related
Ensembl:ENSG00000163762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L6D
Expression
Broad expression in spleen (RPKM 15.9), fat (RPKM 12.5) and 21 other tissues See more
Orthologs
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Genomic context

See TM4SF18 in Genome Data Viewer
Location:
3q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (149318498..149333636, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149036285..149051423, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ceruloplasmin and hephaestin like 1, pseudogene Neighboring gene uncharacterized LOC107986140 Neighboring gene ribosomal protein S25 pseudogene 5 Neighboring gene transmembrane 4 L six family member 1 Neighboring gene TM4SF1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transmembrane 4 L6 family member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184723.2NP_001171652.1  transmembrane 4 L6 family member 18

    See identical proteins and their annotated locations for NP_001171652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093001, BF213446, CA454331
    Consensus CDS
    CCDS3142.1
    UniProtKB/Swiss-Prot
    Q96CE8
    Related
    ENSP00000419278.1, ENST00000470080.5
    Conserved Domains (1) summary
    pfam05805
    Location:1193
    L6_membrane; L6 membrane protein
  2. NM_138786.4NP_620141.1  transmembrane 4 L6 family member 18

    See identical proteins and their annotated locations for NP_620141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093001, BC014339, DB282139
    Consensus CDS
    CCDS3142.1
    UniProtKB/Swiss-Prot
    Q96CE8
    Related
    ENSP00000296059.2, ENST00000296059.7
    Conserved Domains (1) summary
    pfam05805
    Location:1193
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    149318498..149333636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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